Hepatitis B immune serum globulin and standard gamma globulin in prevention of hepatitis B infection among hospital staff
| Autor: | Iwarson S, Hermodsson S, J. Ahlmén, E. Eriksson, C. Ljunggren, H. Kjellman, D. Selander |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
medicine.medical_specialty
Attack rate Hospital Departments Renal Dialysis Internal medicine medicine Humans Hepatitis B Antibodies Seroconversion Kidney transplantation biology business.industry Immunization Passive Antibody titer Gamma globulin General Medicine Hepatitis B Jaundice medicine.disease Kidney Transplantation Personnel Hospital Antibody Formation Immunology biology.protein gamma-Globulins medicine.symptom Antibody business |
| Zdroj: | The American Journal of the Medical Sciences. 270:385-390 |
| ISSN: | 0002-9629 |
| DOI: | 10.1097/00000441-197509000-00022 |
| Popis: | In May 1973 a controlled double-blind clinical trail with prophylactic injects of hepatitis B immune serum globulin (antibody titer by passive hemagglutination 1:355,000) and standard gamma globulin (1:100) was started in Sahlgren's Hospital, Göteborg, Sweden. The annual attack rate of clinical hepatitis B in the three departments studied had been 5 to 8 per cent during recent years. A total of 118 members of the hospital staff were prophylactically treated while 125 staff members were unwilling to participate and received no prophylactic treatment. During the first 20 months of study nine cases of clinical hepatitis B with jaundice occurred within the untreated group (7.2 per cent) while three cases (2.5 per cent) were observed in prophylactically treated individuals. After decoding it was found that 60 individuals had received specific hepatitis B immune serum globulin while 58 had received standard gamma globulin. Two of the three clinical cases of hepatitis B occurred within the standard gamma globulin group. Both groups included two individuals with transient antigenemia only and the standard gamma globulin group also included four individuals with antibody seroconversion. |
| Databáze: | OpenAIRE |
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