Mechanical disfunction in the mucosal oedema formation of patients with nasal polyps
| Autor: | Richard Louis Voegels, Luiz Carlos Gregório, Aldo Cassol Stamm, Claudina Perez-Novo, Pinto Bezerra Tf, Rogério Pezato |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Adolescent medicine.medical_treatment Hydrostatic pressure Mucous membrane of nose Stimulation Sodium Chloride Turbinates Pathogenesis Young Adult Nasal Polyps otorhinolaryngologic diseases medicine Hydrostatic Pressure Edema Humans Nasal polyps Saline Mucosal oedema Aged business.industry General Medicine Middle Aged medicine.disease Pathophysiology Nasal Mucosa Otorhinolaryngology Case-Control Studies Female business |
| Zdroj: | Rhinology. 52(2) |
| ISSN: | 0300-0729 |
| Popis: | Background: Nasal polyposis (NP) is characterized by an anomalous tissue growth with oedema and a lack of extracellular matrix. In this study, we investigated whether a mechanical disfunction of the forces that act in oedema formation is present in NP. Methods: We compared the interstitial hydrostatic pressure behaviour during a saline solution infusion between healthy nasal mucosa (inferior and middle turbinate from 10 patients) and inflamed nasal mucosa from NP patients (inferior, middle turbinate and a nasal polyp from 6 patients). We used Controlled Disc Stimulation equipment to compare the curve Pressure/Volume created during the saline solution infusion. Results: The pressure at 0.2 ml infusion was lower in the middle turbinate of NP patients than in the middle turbinate of control patients. The lowest P/V mean assessed was in the polypoid tissue. Conclusions: The interstitial hydrostatic pressure showed different behaviour during liquid infusion in nasal mucosa from NP patients when compared with healthy nasal mucosa. This study allows us to cogitate on a new pathophysiological mechanism contributing to the development of the NP. |
| Databáze: | OpenAIRE |
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