Pyroptotic cell death in the R6/2 mouse model of Huntington’s disease: new insight on the inflammasome
| Autor: | Emanuela Paldino, Francesca Fusco, Giuseppe Sancesario, Vincenza D'Angelo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Genetically modified mouse Cancer Research Immunology Excitotoxicity Biology Medium spiny neuron medicine.disease_cause lcsh:RC254-282 Article 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Huntington's disease Cellular neuroscience medicine lcsh:QH573-671 Neuroinflammation lcsh:Cytology Pyroptosis Inflammasome Cell Biology medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens 030104 developmental biology nervous system Neuroscience 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Cell Death Discovery, Vol 6, Iss 1, Pp 1-12 (2020) Cell Death Discovery |
| ISSN: | 2058-7716 |
| DOI: | 10.1038/s41420-020-00293-z |
| Popis: | Mechanisms of tissue damage in Huntington’s disease involve excitotoxicity, mitochondrial damage, and neuroinflammation, including microglia activation. In the present study, we investigate the role of pyroptosis process in the striatal neurons of the R6/2 mouse model of Huntington’s disease. Transgenic mice were sacrificed at 4 and 13 weeks of age. After sacrifice, histological and immunohistochemical studies were performed. We found that NLRP3 and Caspase-1 were intensely expressed in 13-week-old R6/2 mice. Moreover, NLRP3 expression levels were higher in striatal spiny projection neurons and in parvalbumin interneurons, which are prone to degenerate in HD. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink