Effect of an Exercise Program on Lymphocyte Proliferative Responses of COPD Patients
| Autor: | Cibele Cristine Berto Marques da Silva, Gil Benard, Alberto José da Silva Duarte, Celso R. F. Carvalho, Regina Carvalho Pinto, Juliana Ruiz Fernandes, Aline Grandi Silva |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Pulmonary and Respiratory Medicine CD4-Positive T-Lymphocytes Male Lymphocyte T-Lymphocytes Vital Capacity Cytomegalovirus Walk Test CD8-Positive T-Lymphocytes medicine.disease_cause Peripheral blood mononuclear cell Haemophilus influenzae 03 medical and health sciences Pulmonary Disease Chronic Obstructive 0302 clinical medicine Immune system Antigen Forced Expiratory Volume Medicine Humans Lymphocytes Phytohemagglutinins Antigens Viral Aged Cell Proliferation IMUNIDADE COPD Antigens Bacterial business.industry Standard treatment CD28 Middle Aged medicine.disease Exercise Therapy 030104 developmental biology medicine.anatomical_structure Dyspnea Ki-67 Antigen 030228 respiratory system Immunology Quality of Life Female business |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 1432-1750 |
| Popis: | Exercise training has been shown to reduce symptoms and exacerbations in COPD patients; however, the exercise effect on patients’ immune response is poorly known. We thus verified if an exercise program (EP) impacted on proliferative T cell response of COPD patients. Fourteen non-O2 dependent COPD patients on standard treatment were studied. EP consisted in 24 sessions of aerobic and muscular training. Peripheral blood mononuclear cells were stimulated with the mitogen phytohemagglutinin and antigens from Haemophilus influenzae and cytomegalovirus, and the lymphocyte proliferative response (LPR) was assessed through the expression of Ki67 before and after the EP. The Quality of life [COPD assessment test (CAT)], dyspnea [(modified Medical Research Council scale (mMRC)], and 6-min walk distance were also assessed. The EP program increased significantly the LPR of TCD4+ lymphocytes to phytohemagglutinin and cytomegalovirus and H. influenzae antigens, but with TCD8+ lymphocytes the increase was less marked. Consistent with this, a higher proportion of TCD8+ than TCD4+ cells did not express the costimulatory molecule CD28. The EP also resulted in improvement of the quality of life, dyspnea, and physical capacity. The improvement in TCD4+ cell function may represent an additional mechanism through which the EP results in less exacerbations and hospitalizations. |
| Databáze: | OpenAIRE |
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