Adenosine phosphonate inhibitors of lipid II: Alanyl tRNA ligase MurM from Streptococcus pneumoniae

Autor:	Gianfranco De Pascale, David I. Roper, Adrian J. Lloyd, Elena Cressina, Timothy D. H. Bugg, Christopher G. Dowson
Rok vydání:	2007
Předmět:	Clinical Biochemistry Pharmaceutical Science Carbon-Oxygen Ligases Biochemistry Microbiology chemistry.chemical_compound Bacterial Proteins Biosynthesis Alanine—tRNA ligase Drug Discovery medicine Peptide Synthases Molecular Biology Antibacterial agent chemistry.chemical_classification Molecular Structure Lipid II Adenine Nucleotides Organic Chemistry Adenosine Phosphonate Uridine Diphosphate N-Acetylmuramic Acid Streptococcus pneumoniae Enzyme chemistry Molecular Medicine medicine.drug
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 17:4654-4656
ISSN:	0960-894X
DOI:	10.1016/j.bmcl.2007.05.071
Popis:	Adenosine and 2′-deoxyadenosine phosphonate transition state analogues act as the first inhibitors for the MurMN/FemABX family of tRNA-dependent ligases implicated in high-level penicillin resistance in Gram-positive bacteria.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11e7dfc0f16a12afd22c924bb2863e54 https://doi.org/10.1016/j.bmcl.2007.05.071 Zobrazit plný text záznamu Full Text from ScienceDirect