Serum adiponectin is associated with body composition and cognitive and psychological status in older adults living in long-term nursing homes
| Autor: | Haritz Arrieta, Chloe Rezola-Pardo, Ana Rodriguez-Larrad, Miren Iturburu, Jon Irazusta, Begoña Sanz, Susana María Gil, Gotzone Hervás, Fátima Ruiz-Litago |
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| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Gerontology Aging Waist Frail Elderly Physical fitness Population Biochemistry 03 medical and health sciences Cognition 0302 clinical medicine Endocrinology Quality of life Genetics medicine Homes for the Aged Humans education Geriatric Assessment Molecular Biology Aged 80 and over education.field_of_study Frailty Adiponectin business.industry Mental Disorders Cell Biology Long-Term Care Nursing Homes Cross-Sectional Studies Mental Health 030104 developmental biology Physical Fitness Body Composition Quality of Life Lean body mass Anxiety Female medicine.symptom business Body mass index Biomarkers 030217 neurology & neurosurgery |
| Zdroj: | Experimental Gerontology. 121:1-9 |
| ISSN: | 0531-5565 |
| DOI: | 10.1016/j.exger.2019.03.005 |
| Popis: | Frailty is a geriatric syndrome characterized by decreasing functional reserves and increasing vulnerability to falls, injuries and declining health, leading to dependence upon caregivers. Frailty is associated not only with physical decline, but also with cognitive and psychological impairments in aging people. Higher serum adiponectin concentration has been linked to better performance on frailty measures but also to worse cognitive status. Nonetheless, several studies have proposed adiponectin as a frailty biomarker. To further delineate the relationship between adiponectin serum levels and frailty-related parameters, we studied a population of 112 long-term nursing home residents (aged 84.9 ± 6.7) and analyzed their serum adiponectin levels in conjunction with frailty-related parameters including body composition, physical fitness, cognitive function, psychological parameters and quality of life. Frailty was assessed following the Fried Frailty Criteria, the Clinical Frailty Scale and the Tilburg Frailty Indicator. In women, higher serum adiponectin levels were associated with lower body weight, body mass index, body fat mass, fat mass/height2, lean mass, lean mass/height2 and smaller waist circumference and hip circumference (p The results of our study show that adiponectin is linked to body composition, cognitive function and anxiety in long-term nursing home residents with differential relationships by sex. Further studies should be conducted to determine whether adiponectin is a valid and reliable frailty biomarker. |
| Databáze: | OpenAIRE |
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