Recurrent and persistent respiratory tract viral infections in patients with primary hypogammaglobulinemia

Autor: Olli Ruuskanen, Tytti Vuorinen, Riikka Österback, Kaisu Rantakokko-Jalava, Leena Kainulainen
Rok vydání: 2009
Předmět:
Adult
Male
medicine.medical_specialty
Rhinovirus
X-linked agammaglobulinemia
hypogammaglobulinemia
respiratory tract infection
Immunology
medicine.disease_cause
Article
Hypogammaglobulinemia
Agammaglobulinemia
Recurrence
XLA
X-linked agammaglobulinemia
Internal medicine
CVID
Common variable immunodeficiency
medicine
Immunology and Allergy
Humans
Prospective Studies
Acute respiratory tract infection
Respiratory Tract Infections
Btk
Bruton tyrosine kinase
Aged
Primary immunodeficiency
Respiratory tract infections
business.industry
Respiratory disease
Sputum
common variable immunodeficiency
Common cold
Middle Aged
medicine.disease
respiratory virus
medicine.anatomical_structure
immunoglobulin replacement therapy
Virus Diseases
Respiratory virus
RSV
Respiratory syncytial virus
Female
business
Respiratory tract
TLR
Toll-like receptor
Zdroj: The Journal of Allergy and Clinical Immunology
ISSN: 1097-6825
Popis: Background The occurrence of respiratory tract viral infections in patients with primary hypogammaglobulinemia has not been studied. Objective We conducted a prospective 12-month follow-up study of respiratory tract infections in 12 adult patients with primary hypogammaglobulinemia. Methods Nasal swab samples and induced sputum samples were taken at the onset of acute respiratory tract infection and every 3 months thereafter. Samples were tested for bacteria and viruses. PCR tests were performed for 15 respiratory tract viruses. In case the results for rhinovirus were positive, follow-up nasal swab samples were taken every 2 weeks until rhinoviral PCR results became negative. Patients completed symptom diaries, which were collected every month. The spouses of the patients served as healthy control subjects. Results During the 12-month period, the 12 patients had 65 episodes of acute respiratory tract infections, and the 11 spouses had 12 acute episodes (P < .001). Respiratory tract viruses were found in sputum in 54% of the infections. Rhinovirus was the most common virus. In more than half of our patients, rhinoviral PCR results stayed positive for more than 2 months. The most long-acting persistence with the same rhinovirus was 4 months. Conclusions Despite adequate immunoglobulin replacement therapy, patients with primary hypogammaglobulinemia have increased susceptibility to respiratory tract viral infections. Rhinoviral infections are frequent and prolonged.
Databáze: OpenAIRE
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