Transplantation of Stem Cells from Human Exfoliated Deciduous Teeth Decreases Cognitive Impairment from Chronic Cerebral Ischemia by Reducing Neuronal Apoptosis in Rats
Autor: | Jianhong Zeng, Shu Zhu, Xu Chen, Yao Liu, Yetao Ju, Dongyu Min |
---|---|
Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
Pathology
medicine.medical_specialty Article Subject business.industry Central nervous system Hippocampus Cell Biology RC31-1245 Transplantation Cell therapy Cerebral circulation Cranial neural crest medicine.anatomical_structure Downregulation and upregulation medicine Stem cell business Internal medicine Molecular Biology Research Article |
Zdroj: | Stem Cells International Stem Cells International, Vol 2020 (2020) |
ISSN: | 1687-966X |
DOI: | 10.1155/2020/6393075 |
Popis: | Stem cells from human exfoliated deciduous teeth (SHED) are a unique postnatal stem cell population with high self-renewal ability that originates from the cranial neural crest. Since SHED are homologous to the central nervous system, they possess superior capacity to differentiate into neural cells. However, whether and how SHED ameliorate degenerative central nervous disease are unclear. Chronic cerebral ischemia (CCI) is a kind of neurological disease caused by long-term cerebral circulation insufficiency and is characterized by progressive cognitive and behavioral deterioration. In this study, we showed that either systemic transplantation of SHED or SHED infusion into the hippocampus ameliorated cognitive impairment of CCI rats in four weeks after SHED treatment by rescuing the number of neurons in the hippocampus area. Mechanistically, SHED transplantation decreased the apoptosis of neuronal cells in the hippocampus area of CCI rats through downregulation of cleaved caspase-3. In summary, SHED transplantation protected the neuronal function and reduced neuronal apoptosis, resulting in amelioration of cognitive impairment from CCI. Our findings suggest that SHED are a promising stem cell source for cell therapy of neurological diseases in the clinic. |
Databáze: | OpenAIRE |
Externí odkaz: | |
Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |