H2-Receptor Blockade and Stimulation of Histidine Decarboxylase
| Autor: | Yutaka Kobayashi, David V. Maudsley, Larry Bovaird, Ethel Williamson |
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| Rok vydání: | 1973 |
| Předmět: |
Male
Carboxy-Lyases Receptors Drug Mepyramine Metiamide Pharmacology General Biochemistry Genetics and Molecular Biology Histamine receptor chemistry.chemical_compound Histamine H2 receptor medicine Gastric mucosa Animals Histidine Carbon Radioisotopes Stomach Imidazoles Thiourea General Medicine Burimamide Histidine decarboxylase Stimulation Chemical Rats medicine.anatomical_structure chemistry Food Gastric Mucosa Enzyme Induction Histamine H1 Antagonists Histamine medicine.drug |
| Zdroj: | Nature New Biology. 245:148-149 |
| ISSN: | 2058-1092 0090-0028 |
| DOI: | 10.1038/newbio245148a0 |
| Popis: | IT has been apparent for some time that the responses of certain tissues to histamine are not blocked by the classical anti-histaminic drugs such as mepyramine or chlorpheniramine. Two types of histamine receptor have been recognized, H1-receptors which are blocked by mepyramine and H2-receptors which are not1. Responses to histamine mediated through interaction with H2-receptors include increases in heart rate, inhibition of uterine contractility and the secretion of acid by the gastric mucosa. Last year Black and his co-workers reported the results of an extensive series of studies characterizing H2-receptors and showed that burimamide, a thiourea derivative of histamine, is a specific H2-receptor antagonist2,3. Burimamide inhibits, for example, the increase in acid secretion evoked by injections of histamine but does not block histamine induced contractions of guinea-pig ileum unless very high doses are used. We report here an unexpected effect on histamine biosynthesis in the rat glandular stomach produced by two H2-receptor antagonists, burimamide and metiamide. |
| Databáze: | OpenAIRE |
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