Development of a multi-class method to determine nitroimidazoles, nitrofurans, pharmacologically active dyes and chloramphenicol in aquaculture products by liquid chromatography-tandem mass spectrometry
| Autor: | Dominique Hurtaud-Pessel, Jean-Michel Delmas, Dongmei Chen, Eric Verdon |
|---|---|
| Přispěvatelé: | National Reference Laboratory of Veterinary Drug Residues, Laboratoire de Fougères - ANSES, Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
chloramphenicol
analysis analyse nitrofurane 02 engineering and technology veterinary drug 01 natural sciences Analytical Chemistry residues Tandem Mass Spectrometry Liquid chromatography–mass spectrometry Furaltadone Sample preparation Veterinary drug masse spectrométrie liquid chromatography-tandem mass spectrometry Coloring Agents Nitrofuran chimie Chemistry Fishes Furazolidone General Medicine 021001 nanoscience & nanotechnology Anti-Bacterial Agents aquaculture Nitroimidazoles 0210 nano-technology medicine.drug médicament vétérinaire medicine.drug_class Food Contamination nitrofuran Quechers chemistry [CHIM.ANAL]Chemical Sciences/Analytical chemistry medicine Animals LC-MS/MS colorant Chromatography dye résidues 010401 analytical chemistry Drug Residues 0104 chemical sciences chromatographie liquide nitroimidazole aquaculture product Chromatography Liquid Food Science Nifuroxazide |
| Zdroj: | Food Chemistry Food Chemistry, Elsevier, 2020, 311, pp.125924. ⟨10.1016/j.foodchem.2019.125924⟩ |
| ISSN: | 0308-8146 |
| DOI: | 10.1016/j.foodchem.2019.125924⟩ |
| Popis: | International audience; LC-MS/MS method was developed for the efficient identification and quantification of 21 banned substances including various nitroimidazoles, nitrofurans, pharmacologically-active dyes and chloramphenicol, respectively in aquaculture products. The sample preparation was started by acid-treatment with 2-nitrobenzaldehyde (NBA) to liberate matrix-bound residues of nitrofurans. A modified QuEChERS method was optimized for the extraction and clean-up of the target analytes. The metabolites of the four conventional nitrofurans (nitrofurantoin, furazolidone, nitrofurazone and furaltadone) and of three other nitrofurans (nifursol, nifuroxazide, and nitrovin), and an underivatizable nitrofuran (nifurpirinol) were simultaneously detected. Furthermore, 21 banned substances were quantified by LC-MS/MS with ESI using one single injection. To evaluate and validate the performance of the method the criteria of the Decision (EC) no 2002/657 were applied. Decision limit (CCα) of target analytes ranged 0.067-1.655 μg/kg in aquaculture products. The recovery ranged 77.2%-125.6%, and the relative standard deviations of inter-day analyses (RSD) were less than 25%. |
| Databáze: | OpenAIRE |
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