Correlation between age-related changes in open field behavior and plaque forming cell response in DA female rats
| Autor: | Stanislava Stanojević, Jelena Radulovic, Tatjana Miletić, Olgica Laban, Cedomir Todorovic, Mirjana Dimitrijević, Vesna Kovačević-Jovanović |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Senescence
medicine.medical_specialty Aging Neuroimmunomodulation Pain Hemolytic Plaque Technique Open field Developmental psychology Immune system forced-swim test plaque forming cell response Internal medicine medicine Animals rat open field Innate immune system Depression General Neuroscience Macrophages analgesia Rats Inbred Strains General Medicine Acquired immune system macrophages Rats Endocrinology Nociception Ageing Immune System Antibody Formation Exploratory Behavior Female Psychology Behavioural despair test |
| Zdroj: | International Journal of Neuroscience |
| ISSN: | 0020-7454 |
| Popis: | We investigated the relationship between immunological and behavioral changes during ageing in Dark Agouti female rats. Results showed that ageing was associated with decreased exploratory behavior and increased emotionality (open field test) and decreased pain perception (writhing assay), but not with altered depression-like behavior (forced swim test). The observed behavioral changes were paralleled with decreased innate immunity in middle-aged and old rats, as revealed by reduced peroxide production of peritoneal macrophages; and decreased specific immunity, measured by the plaque-forming cell response, in old rats in comparison with young rats. Correlation analyses between behavioral and immune parameters demonstrated a significant correlation between the lines crossed in the open field test and the plaque-forming cell response. Taken together, the demonstrated age-dependent association between exploratory behavior and specific immune response suggests a senescent decline of a common neuroimmune regulatory mechanism. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|