Ultrashort Bradycardic Effect of Newly Synthesized Compounds
Autor: | Josef Krčmář, V. Strnadová, Jana Kolevska, V. Brunclík, Klára Beránková, Ladislava Bartošová, Tomáš Florian, G. Vaculová, Radka Opatřilová, Markéta Bébarová, Lenka Bartošíková, Jiří Nečas, Marek Frydrych, P. Mokrý |
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Rok vydání: | 2006 |
Předmět: |
medicine.medical_specialty
Adrenergic receptor Potassium chemistry.chemical_element Experimental pharmacology 030204 cardiovascular system & hematology Pharmacology ester-functional group 030226 pharmacology & pharmacy Sodium current 03 medical and health sciences 0302 clinical medicine Internal medicine Heart rate heart rate medicine Receptor lcsh:Veterinary medicine General Veterinary Chemistry Esmolol 3. Good health Blockade rats Endocrinology bradycardic effect lcsh:SF600-1100 membrane currents medicine.drug |
Zdroj: | Acta Veterinaria Brno, Vol 75, Iss 2, Pp 183-196 (2006) |
ISSN: | 1801-7576 0001-7213 |
Popis: | Changes in the heart rate induced by four different doses of two newly synthesized potential ultrashort-action antagonists of beta adrenergic receptors were tested in 90 male laboratory Wistar rats. The isoprenaline-induced tachycardia model was used. Their effects were compared with those of esmolol. In the second part of the study, approximate electro-physiological measurements were made in vitro to assess the influence of the compounds tested on ion membrane currents in isolated ventricular cardiomyocytes. Both compounds demonstrated significant bradycardic effects in all concentrations tested compared with the control group, but they differed in the time of the onset of their action. Both newly synthesized compounds induced blockade of the fast sodium current (INa) and potassium currents (Ito, IK1, IK,end). |
Databáze: | OpenAIRE |
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