Renal Denervation and Celiac Ganglionectomy Decrease Mean Arterial Pressure Similarly in Genetically Hypertensive Schlager (BPH/2J) Mice
| Autor: | Madeline M. Gauthier, Hannah Garver, Abhismitha Ramesh, Christopher T. Banek, John W. Osborn, Ninitha Asirvatham-Jeyaraj, Gregory D. Fink |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Mean arterial pressure Sympathetic Nervous System hypertension medicine.medical_treatment Blood Pressure Femoral artery 030204 cardiovascular system & hematology Kidney 03 medical and health sciences Mice cause of death 0302 clinical medicine Heart Rate medicine.artery Internal medicine Heart rate Internal Medicine Medicine Animals In patient Arterial Pressure Ganglionectomy Cause of death Denervation business.industry Original Articles femoral artery Renal Denervation Blood pressure Cardiology ComputingMethodologies_DOCUMENTANDTEXTPROCESSING business 030217 neurology & neurosurgery |
| Zdroj: | Hypertension (Dallas, Tex. : 1979) |
| ISSN: | 1524-4563 |
| Popis: | Supplemental Digital Content is available in the text. Renal denervation (RDNX) lowers mean arterial pressure (MAP) in patients with resistant hypertension. Less well studied is the effect of celiac ganglionectomy (CGX), a procedure which involves the removal of the nerves innervating the splanchnic vascular bed. We hypothesized that RDNX and CGX would both lower MAP in genetically hypertensive Schlager (BPH/2J) mice through a reduction in sympathetic tone. Telemeters were implanted into the femoral artery in mice to monitor MAP before and after RDNX (n=5), CGX (n=6), or SHAM (n=6). MAP, systolic blood pressure, diastolic blood pressure, and heart rate were recorded for 14 days postoperatively. The MAP response to hexamethonium (10 mg/kg, IP) was measured on control day 3 and postoperative day 10 as a measure of global neurogenic pressor activity. The efficacy of denervation was assessed by measurement of tissue norepinephrine. Control MAP was similar among the 3 groups before surgical treatments (≈130 mm Hg). On postoperative day 14, MAP was significantly lower in RDNX (−11±2 mm Hg) and CGX (−11±1 mm Hg) groups compared with their predenervation values. This was not the case in SHAM mice (−5±3 mm Hg). The depressor response to hexamethonium in the RDNX group was significantly smaller on postoperative day 10 (−10±5 mm Hg) compared with baseline control (−25±10 mm Hg). This was not the case in mice in the SHAM (day 10; −28±5 mm Hg) or CGX (day 10; −34±7 mm Hg) group. In conclusion, both renal and splanchnic nerves contribute to hypertension in BPH/2J mice, but likely through different mechanisms. |
| Databáze: | OpenAIRE |
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