Near Full-Length Genomic Characterization of HIV-1 CRF01_AE/B Recombinant Strains Identified in Hebei, China
| Autor: | Kang Li, Fan Li, Hao Liang, Zhangwen Ge, Weidong Ou, Yi Feng, Yiming Shao, Jia Sun, Qiao Huang, Hui Xing |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine China viruses Immunology Population Human immunodeficiency virus (HIV) HIV Infections Genome Viral Biology medicine.disease_cause Genome law.invention Young Adult 03 medical and health sciences 0302 clinical medicine immune system diseases law Virology medicine Humans 030212 general & internal medicine Homosexuality Male education Phylogeny Genetics education.field_of_study Phylogenetic tree Strain (biology) Breakpoint Genetic Variation virus diseases Male individual Genomics Sequence Analysis DNA 030104 developmental biology Infectious Diseases HIV-1 Recombinant DNA RNA Viral Reassortant Viruses |
| Zdroj: | AIDS Research and Human Retroviruses. 35:196-204 |
| ISSN: | 1931-8405 0889-2229 |
| DOI: | 10.1089/aid.2018.0130 |
| Popis: | This study reports a novel HIV-1 recombinant form of CRF01_AE/B that was isolated from a 22-year-old male individual (HE150308) residing in Hebei province, China. The near full-length genome (NFLG) phylogenetic tree showed that the strain was clustered with CRF01_AE reference sequences and placed at the peripheral position within the branch of CRF01_AE strains. The bootscaning and similarity plot analysis revealed that the NFLG of this novel recombinant was composed of eight interlaced segments, including four CRF01_AE and four subtype B segments separated by seven breakpoints observed in the gag, pol, and nef regions of HIV-1 genome. Phylogenetic analysis demonstrated that the CRF01_AE subregions were from the previously identified CRF01_AE cluster 5, and the B subregions were correlated with the B strains originated from Europe and America. They were all the lineages widely prevalent in men who have sex with men (MSM) population in China. In recent years, a large number of recombinants between CRF01_AE and B strains are constantly emerging in the MSM population in China. This continual and recurrent recombination between CRF01_AE and B in high-risk group people deserves more attention and further monitoring. |
| Databáze: | OpenAIRE |
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