Cortical and subcortical chemical pathology in Alzheimer's disease as assessed by multislice proton magnetic resonance spectroscopic imaging
| Autor: | J.H. Duyn, L. Verhagen Metman, Nicholas J. Patronas, Alessandro Bertolino, G. Di Chiro, T. N. Chase, Simona Bonavita, N. Lundbom, Gioacchino Tedeschi |
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| Přispěvatelé: | Tedeschi, Gioacchino, Bertolino, A, Lundbom, N, Bonavita, Simona, Patronas, Nj, Duyn, Jh, Metman, Lv, Chase, Tn, DI CHIRO, G. |
| Rok vydání: | 1996 |
| Předmět: |
Brain Mapping
Pathology medicine.medical_specialty medicine.diagnostic_test Brain Magnetic resonance imaging Middle Aged Creatine Magnetic Resonance Imaging Brain mapping Phosphocreatine White matter chemistry.chemical_compound medicine.anatomical_structure chemistry Alzheimer Disease medicine Humans Choline Multislice Neurology (clinical) Protons Aged Phosphocholine |
| Zdroj: | Neurology. 47:696-704 |
| ISSN: | 1526-632X 0028-3878 |
| DOI: | 10.1212/wnl.47.3.696 |
| Popis: | Background: Multislice proton magnetic resonance spectroscopic imaging (1H-MRSI) permits the simultaneous acquisition of N-acetylaspartate (NA), choline (Cho), creatine/phosphocreatine (Cre), and lactate (Lac) signal intensities from four 15-mm slices divided into 0.84-ml single-volume elements. NA is inferred to be a neuron-specific molecule, whereas Cho mainly reflects glycerophosphocholine and phosphocholine, compounds involved in phospholipid metabolism. Objective: To assess whether 1H-MRSI could detect a regional pattern of cortical and subcortical involvement in the brain of Alzheimer's disease (AD) patients. Methods: 1H-MRSI was performed in 15 patients with probable AD and 15 age-matched healthy controls. Regions of interest (ROIs) were selected from frontal (FC), temporal (TC), parietal (PC), occipital, and insular cortices, subcortical white matter (WM), and thalamus. Results: In AD patients, we found a significant reduction of NA/Cre in the FC, TC, and PC and a significant reduction of Cho/Cre in the WM. Conclusions: This 1H-MRSI study of AD patients shows a regional pattern of neuronal damage in the associative cortices, as revealed by significant reduction of NA/Cre in the FC, TC, and PC, and regional derangement of phospholipid metabolism, as revealed by significant reduction of Cho/Cre in the WM.NEUROLOGY 1996;47: 696-704 |
| Databáze: | OpenAIRE |
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