X-linked juvenile retinoschisis (RS) maps between DXS987 and DXS443
| Autor: | M. T. Roesch, Bernhard H. F. Weber, S. Sander, A. E. Gibson, Gudrun Vogt, S. Janocha, Cecil C. Ewing |
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| Rok vydání: | 1995 |
| Předmět: |
Genetic Markers
Male Genetics Polymorphism Genetic X Chromosome Base Sequence Molecular Sequence Data Chromosome Mapping Locus (genetics) DNA Satellite Biology Pedigree Haplotypes Retinal Diseases Gene mapping Humans Female Crossing Over Genetic Juvenile retinoschisis Molecular Biology Genetics (clinical) X chromosome DNA Primers Repetitive Sequences Nucleic Acid |
| Zdroj: | Europe PubMed Central |
| ISSN: | 1424-859X 1424-8581 |
| DOI: | 10.1159/000133932 |
| Popis: | X-linked juvenile retinoschisis (RS) has previously been localized to a 7–8 cM interval between markers at (DXS43, DXS207) and (DXS274, DXS41). Our analysis of more than 300 meioses in two multigeneration RS families identified eight recombinant RS chromosomes and narrowed the RS locus to an interval between DXS987 and DXS443. Our data suggest the following order of loci: Xpter – DXS207 -DXS987 – ([DXS418 – DXS999], RS) – DXS443 – DXS365 – DXS274 – Xcen. |
| Databáze: | OpenAIRE |
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