The impact of dietary induced hyperparathyroidism on healthy and diseased periodontia: an experimental study in rats
| Autor: | Umur Sakallıoğlu, Pınar Gürgör, Sancar Baris, Elif Eser Sakallıoğlu, Müge Lütfioğlu |
|---|---|
| Přispěvatelé: | Hitit Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Ondokuz Mayıs Üniversitesi |
| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty Pathology medicine.medical_treatment periodontal disease Alveolar Bone Loss Osteoclasts Cell Count Gastroenterology Rats Sprague-Dawley Periodontal Disease Osteoclast Internal medicine medicine Animals host modifying factors Dietary Induced Hyperparathyroidism Saline Nutrition Periodontitis Hyperparathyroidism business.industry Periodontium medicine.disease Gingivitis Rats Calcium Dietary Endotoxins dietary induced hyperparathyroidism nutrition medicine.anatomical_structure Chronic Periodontitis Standard diet Cytokines Periodontics Hyperparathyroidism Secondary Host Modifying Factors business Mandibular molar Pocket formation |
| Zdroj: | Journal of Clinical Periodontology. 39:264-271 |
| ISSN: | 0303-6979 |
| Popis: | Sakallioglu, Umur/0000-0002-8823-755X; LUTFIOGLU, MUGE/0000-0003-1499-5902 WOS: 000299635500007 PubMed: 22093080 Background and Objective: Nutrition may be a potential modifying factor in periodontal conditions. The present study investigated this phenomenon for dietary induced hyperparathyroidism (dHPT) by revealing the histopathological and histomorphometrical profiles of healthy and diseased periodontia in dHPT. Methods: Dietary induced hyperparathyroidism was induced in 12 rats by dietary calcium/phosphorous imbalance and 12 rats were fed standard diet (SD). Periodontitis was induced on the right mandibular molar teeth (mmt) of these rats by injecting an endotoxin + saline solution whereas injecting pure saline to the left mmt. Thus, four study groups were created: dHPT + saline (group 1), dHPT + endotoxin (group 2), SD + endotoxin (group 3) and SD + saline (group 4). Histological sections were obtained from the second mmt and examined using light microscope. Results: Group 1 demonstrated inflammatory and degenerative alterations in periodontium without pocket formation. Periodontitis was evident in groups 2 and 3. Group 2 revealed the highest amounts of gingival inflammatory cell and vessel counts (group 2 > group 3 > group 1 > group 4), attachment and bone losses (group 2 > group 3 > groups 1 > group 4) and osteoclast count (group 2 > group 3 > group 1 > group 4) (p < 0.05). Conclusion: These results propose that dHPT may impair the health status of periodontium and may worsen the pathobiology of periodontal diseases. Ondokuz Mayis UniversityOndokuz Mayis University This study was supported by the Scientific Research Fund of Ondokuz Mayis University. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text