PIRs Mediate Innate Myeloid Cell Memory to Nonself MHC Molecules
| Autor: | Tengfang Li, Khodor I. Abou-Daya, Sebastien Gingras, Hiromi Kubagawa, Peter Nickerson, Matthew L. Nicotra, Wenhao Chen, Jayne S. Danska, Peixiang Lan, Eiji Takayama, Chris Wiebe, Lisa R. Mathews, Steven M. Mortin-Toth, Jianjiao Chen, Heth R. Turnquist, Wentao Liu, Hehua Dai, Wei Chen, Daqiang Zhao, Amanda L. Williams, Andrew J. Friday, Tao Sun, Martin H. Oberbarnscheidt, Fadi G. Lakkis, Xian Chang Li, Mark J. Shlomchik |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Graft Rejection Myeloid medicine.medical_treatment Immunology Immunological memory Major histocompatibility complex Ly49 Article Monocytes MHC-1 03 medical and health sciences Mice 0302 clinical medicine specific innate immune memory Antigen Immunity medicine Animals Myeloid Cells Receptors Immunologic Receptor Heart transplantation Mice Inbred BALB C Multidisciplinary biology General Commentary Macrophages Histocompatibility Antigens Class I differentiation Kidney Transplantation Immunity Innate Mice Mutant Strains Cell biology 030104 developmental biology medicine.anatomical_structure PIR-A 030220 oncology & carcinogenesis Cell memory biology.protein Heart Transplantation Immunologic Memory NK Cell Lectin-Like Receptor Subfamily A Gene Deletion |
| Zdroj: | Frontiers in Immunology Science |
| ISSN: | 1664-3224 |
| Popis: | Innate immune cells remember Immunological memory is a phenomenon by which immune cells can quickly recognize an antigen that the host has previously encountered. Certain cells of the innate immune system exhibit memory-like responses know as trained immunity. Rapid, antigen-specific secondary (anamnestic) responses were long thought to be the domain of B and T cells. However, Dai et al. report that monocytes and macrophages can acquire memory specific for particular major histocompatibility complex I antigens using paired A-type immunoglobulin-like receptors (PIR-As) (see the Perspective by Dominguez-Andrés and Netea). This pathway contributes to recognition and rejection of allograft-transplanted tissue from a donor of the same species. Genetic depletion or blockade of PIR-As in mice diminished the rejection of kidney and heart allografts. This work, which expands immunological memory to include myeloid cells, points to targets that may improve organ transplantation outcomes in the future. Science , this issue p. 1122 ; see also p. 1052 |
| Databáze: | OpenAIRE |
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