Effect of Hancornia speciosa aqueous extract treatment on biochemical parameters in diabetic pregnant rats
| Autor: | Madilene Francely Américo, Leila S. Neto, Thaigra de Sousa Soares, Kleber Eduardo de Campos, Rafaianne Queiroz de Moraes Souza, Débora Cristina Damasceno, Gustavo Tadeu Volpato, Daniela Gomes Alves |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
biology business.industry Cholesterol Endocrinology Diabetes and Metabolism Glutathione Pharmacology Streptozotocin medicine.disease_cause medicine.disease Malondialdehyde Superoxide dismutase chemistry.chemical_compound Endocrinology chemistry Internal medicine Diabetes mellitus Meeting Abstract Internal Medicine medicine biology.protein business Oxidative stress medicine.drug Glycemic |
| Zdroj: | Diabetology & Metabolic Syndrome |
| ISSN: | 1758-5996 |
| Popis: | Materials and methods Diabetes was induced by streptozotocin (40 mg/Kg) in virgin female Wistar rats. After diabetes induction, rats were mated. The pregnant diabetic rats were put in four experimental groups, with n minimum=12 animals/ group: Non-diabetic; Non-diabetic Treated; Diabetic and Diabetic Treated. Hancornia speciosa leaf aqueous extract (600 mg/kg) was daily administered in all gestational period. On days 0, 7, 14 and 21 the glycemia were measured. On day 21 of pregnancy, all rats were anesthetized and killed. The blood and liver were collected. The biochemical parameters were analyzed for blood (glucose, alanine aminotransferase [ALT], total protein, total cholesterol, triglycerides, High Density Level [HDL]-cholesterol) and also in liver (malondialdehyde [MDA], superoxide dismutase [SOD], catalase, total glutathione, thiol group) for oxidative stress. Analysis of variance followed by Tukey's test were used. Differences were considered statistically significant when p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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