Progressive outer retinal necrosis caused by herpes simplex virus type 1 in a patient with acquired immunodeficiency syndrome
| Autor: | Hiroshi Minoda, Norio Usui, Takuya Iwasaki, Takeshi Kurata, Masahiko Usui, Tetsutaro Sata, Yasuyuki Yamauchi, Mitsutoshi Kashiwase |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty genetic structures viruses Posterior pole Retinitis Progressive outer retinal necrosis Cytomegalovirus Eye Infections Viral Herpesvirus 1 Human medicine.disease_cause Immunoenzyme Techniques Fatal Outcome medicine Humans Antigens Viral Retina AIDS-Related Opportunistic Infections business.industry Retinal vasculitis Herpes Simplex Retinal Necrosis Syndrome Acute Eye infection medicine.disease eye diseases medicine.infectious_disease Ophthalmology Herpes simplex virus medicine.anatomical_structure Immunology Cytomegalovirus Retinitis Disease Progression sense organs business Retinopathy |
| Zdroj: | Ophthalmology. 107(4) |
| ISSN: | 0161-6420 |
| Popis: | Objective/background To identify the etiologic agent of rapidly progressive outer retinal necrosis (PORN) in a 32-year-old man with acquired immunodeficiency syndrome (AIDS), who had retinitis developed from cytomegalovirus (CMV). Multiple yellowish spots appeared in the deep retina without evidence of intraocular inflammation or retinal vasculitis, diagnosed clinically as PORN. Death occurred after failure of multiple organs. Design Case report. Methods Both globes were taken at autopsy, fixed in formalin, and examined histopathologically and immunohistochemically to identify causative agents in the retinal lesions. Main outcome measure Immunohistochemistry. Results All layers of the retina were severely damaged and contained focal calcification. Cytomegalic inclusion bodies were found in cells in the damaged retina of the right eye. Immunohistochemical studies for herpesviruses revealed the presence of CMV antigens in the right retina at the posterior pole and herpes simplex virus type 1 (HSV-1)–specific antigen in the periphery of both retinas. No varicella-zoster virus (VZV) antigen was detected in either retina. Conclusions PORN has been described as a variant of necrotizing herpetic retinopathy, occurring particularly in patients with AIDS. Although the etiologic agent has been reported to be VZV, HSV-1 can be an etiologic agent. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|