U-shape short-range extrinsic connectivity organisation around the human central sulcus

Autor: Olivier Coulon, Alexandre Pron, Christine Deruelle
Přispěvatelé: Institut de Neurosciences de la Timone (INT), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), ANR-16-CONV-0002,ILCB,ILCB: Institute of Language Communication and the Brain(2016)
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Adult
Male
Histology
Computer science
[SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging
[SDV]Life Sciences [q-bio]
Models
Neurological
Context (language use)
Neuroimaging
Biology
U-fibre
050105 experimental psychology
030218 nuclear medicine & medical imaging
Diffusion MRI
03 medical and health sciences
Young Adult
0302 clinical medicine
medicine
Range (statistics)
Humans
0501 psychology and cognitive sciences
Spatial organization
ComputingMilieux_MISCELLANEOUS
Cerebral Cortex
[SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior
Central sulcus
Structural connectivity
General Neuroscience
05 social sciences
[SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences
Human brain
Sulcus
medicine.anatomical_structure
Anatomical connectivity
Diffusion Magnetic Resonance Imaging
Female
Anatomy
Nerve Net
Cartography
[SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing
030217 neurology & neurosurgery
Zdroj: Brain Structure and Function
Brain Structure and Function, Springer Verlag, In press, ⟨10.1007/s00429-020-02177-5⟩
Brain Structure and Function, In press, ⟨10.1007/s00429-020-02177-5⟩
Brain Structure and Function, 2021, 226 (1), pp.179-193. ⟨10.1007/s00429-020-02177-5⟩
ISSN: 1863-2653
1863-2661
DOI: 10.1007/s00429-020-02177-5⟩
Popis: The central sulcus is probably one of the most studied folds in the human brain, owing to its clear relationship with primary sensory-motor functional areas. However, due to the difficulty of estimating the trajectories of the U-shape fibres from diffusion MRI, the short structural connectivity of this sulcus remains relatively unknown. In this context, we studied the spatial organization of these U-shape fibres along the central sulcus. Based on high quality diffusion MRI data of 100 right-handed subjects and state-of-the-art pre-processing pipeline, we first define a connectivity space that provide a comprehensive and continuous description of the short-range anatomical connectivity around the central sulcus at both the individual and group levels. We then infer the presence of five major U-shape fibre bundles at the group level in both hemispheres by applying unsupervised clustering in the connectivity space. We propose a quantitative investigation of their position and number of streamlines as a function of phenotypic traits such as sex and hemispheres and functional scores such as handedness and manual dexterity. Main findings of this study are twofold: a description of U-shape short-range connectivity along the central sulcus at group level and the evidence of a significant relationship between the position of three hand related U-shape fibre bundles and the handedness score of subjects.
Databáze: OpenAIRE
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