Dynamic protein palmitoylation in cellular signaling
| Autor: | Jun Noritake, Yuko Fukata, Masaki Fukata, Ryouhei Tsutsumi, Tsuyoshi Iwanaga |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Cell signaling
Lipoylation Cellular homeostasis medicine.disease_cause Proteomics Biochemistry Substrate Specificity Palmitoylation Yeasts Protein targeting medicine Animals Humans Protein palmitoylation Gap-43 protein biology Intracellular Signaling Peptides and Proteins Intracellular Membranes Cell Biology Plants Cell biology biology.protein lipids (amino acids peptides and proteins) Lipid modification Acyltransferases |
| Zdroj: | Progress in Lipid Research. 48:117-127 |
| ISSN: | 0163-7827 |
| DOI: | 10.1016/j.plipres.2009.02.001 |
| Popis: | Protein S-palmitoylation, the most common lipid modification with the 16-carbon fatty acid palmitate, provides an important mechanism for regulating protein trafficking and function. The unique reversibility of protein palmitoylation allows proteins to rapidly shuttle between intracellular membrane compartments. Importantly, this palmitate cycling can be regulated by some physiological stimuli, contributing to cellular homeostasis and plasticity. Although the enzyme responsible for protein palmitoylation had been long elusive, DHHC family proteins, conserved from plants to mammals, have recently emerged as palmitoyl acyl transferases. Integrated approaches including advanced proteomics, live-cell imaging, and molecular genetics are beginning to clarify the molecular machinery for palmitoylation reaction in diverse aspects of cellular functions. |
| Databáze: | OpenAIRE |
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