Combined effects of ethanol and manganese on cultured neurons and glia
| Autor: | Frederick C. Wedler, P. Kopp, Marc Ledig, L. Megias-Megias, G. Tholey |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Free Radicals
Central nervous system Nerve Tissue Proteins Biology Biochemistry Superoxide dismutase Cellular and Molecular Neuroscience Glutamate-Ammonia Ligase Glutamine synthetase medicine Animals Cells Cultured Free-radical theory of aging Neurons Manganese Ethanol Superoxide Dismutase Nervous tissue General Medicine Rats medicine.anatomical_structure Cell culture Phosphopyruvate Hydratase biology.protein Neuroglia Neuron |
| Zdroj: | Neurochemical Research. 16:591-596 |
| ISSN: | 1573-6903 0364-3190 |
| Popis: | Manganese is essential for normal development and activity of the nervous tissue. Mn2+ ions are involved in protein synthesis and may prevent free radical damage. Since it is now established that alcohol degradation may produce free radicals, we studied the effect of Mn2+ on ethanol induced alterations using cultured nerve cells as an experimental model of the central nervous system. Neurons and glial cells were cultured from rat brain cortex; a tumoral rat glial cell line (C6) was also examined. We measured enzymatic markers of nerve cell maturation (enolase, glutamine synthetase) and superoxide dismutase, a scavenger of free radicals; all these enzymes being activated by Mn2+ ions. Only for the glial cell types an alcohol antagonizing effect was found when Mn2+ was combined with ethanol. Neurons were not sensitive to that Mn2+ effect. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink