Importance of Age of Onset in Pancreatic Cancer Kindreds
| Autor: | Kieran Brune, Ralph H. Hruban, Emily Palmisano, Marcia I. Canto, Alison P. Klein, Michael Goggins, Bryan Lau |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Pancreatic disease Population Gastroenterology 03 medical and health sciences 0302 clinical medicine Pancreatic cancer Internal medicine Odds Ratio medicine Humans Genetic Predisposition to Disease Age of Onset Family history education Aged education.field_of_study business.industry Incidence Hazard ratio Cancer Articles Odds ratio Middle Aged medicine.disease United States 3. Good health Pancreatic Neoplasms Endocrinology Oncology 030220 oncology & carcinogenesis Female 030211 gastroenterology & hepatology Age of onset business SEER Program |
| Zdroj: | JNCI Journal of the National Cancer Institute |
| ISSN: | 1460-2105 0027-8874 |
| Popis: | Background Young-onset cancer is a hallmark of many familial cancer syndromes, yet the implications of young-onset disease in predicting risk of pancreatic cancer among familial pancreatic cancer (FPC) kindred members remain unclear. Methods To understand the relationship between age at onset of pancreatic cancer and risk of pancreatic cancer in kindred members, we compared the observed incidence of pancreatic cancer in 9040 individuals from 1718 kindreds enrolled in the National Familial Pancreas Tumor Registry with that observed in the general US population (Surveillance, Epidemiology, and End Results). Standardized incidence ratios (SIRs) were calculated for data stratified by familial vs sporadic cancer kindred membership, number of affected relatives, youngest age of onset among relatives, and smoking status. Competing risk survival analyses were performed to examine the risk of pancreatic cancer and risk of death from other causes according to youngest age of onset of pancreatic cancer in the family and the number of affected relatives. Results Risk of pancreatic cancer was elevated in both FPC kindred members (SIR = 6.79, 95% confidence interval [CI] = 4.54 to 9.75, P < .001) and sporadic pancreatic cancer (SPC) kindred members (SIR = 2.41, 95% CI = 1.04 to 4.74, P = .04) compared with the general population. The presence of a young-onset patient ( |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|