Effects of Exogenous Androgens on Platelet Activity and Their Thrombogenic Potential in Supraphysiological Administration: A Literature Review
| Autor: | Adrian Rosca, Bogdan Ovidiu Popescu, S. Gologan, Constantin Caruntu, Ana-Maria Vladareanu, Minodora Onisâi, Corin Badiu, Radu Mirica, Suzana Elena Voiculescu, Leon Zagrean, Alina Mititelu |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
platelet reactivity
medicine.medical_treatment Population lcsh:Medicine Review anabolic androgenic steroids platelet activity 030204 cardiovascular system & hematology Bioinformatics Androgen Excess hemostasis/haemostasis 03 medical and health sciences 0302 clinical medicine prothrombotic state Fibrinolysis medicine Platelet Platelet activation education thrombosis Testosterone education.field_of_study thrombotic diathesis thrombopoiesis business.industry lcsh:R androgens General Medicine platelet count AAS platelet aggregation Hemostasis testosterone Animal studies business 030217 neurology & neurosurgery |
| Zdroj: | Journal of Clinical Medicine, Vol 10, Iss 147, p 147 (2021) Journal of Clinical Medicine |
| ISSN: | 2077-0383 |
| DOI: | 10.3390/jcm10010147 |
| Popis: | Anabolic androgenic steroids (AAS), simply called “androgens”, represent the most widespread drugs used to enhance performance and appearance in a sporting environment. High-dosage and/or long-term AAS administration has been associated frequently with significant alterations in the cardiovascular system, some of these with severe endpoints. The induction of a prothrombotic state is probably the most life-threatening consequence, suggested by numerous case reports in AAS-abusing athletes, and by a considerable number of human and animal studies assessing the influence of exogenous androgens on hemostasis. Despite over fifty years of research, data regarding the thrombogenic potential of exogenous androgens are still scarce. The main reason is the limited possibility of conducting human prospective studies. However, human observational studies conducted in athletes or patients, in vitro human studies, and animal experiments have pointed out that androgens in supraphysiological doses induce enhanced platelet activity and thrombopoiesis, leading to increased platelet aggregation. If this tendency overlaps previously existing coagulation and/or fibrinolysis dysfunctions, it may lead to a thrombotic diathesis, which could explain the multitude of thromboembolic events reported in the AAS-abusing population. The influence of androgen excess on the platelet activity and fluid–coagulant balance remains a subject of debate, urging for supplementary studies in order to clarify the effects on hemostasis, and to provide new compelling evidence for their claimed thrombogenic potential. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |