Naltrindole administration during the preweanling period and manipulation affect adrenocortical reactivity in young rats
| Autor: | Carmen Guaza, Ma.Paz Viveros, M. L. Pinillos, Israel Alberti, Ma.Teresa Antelo, B. Fernández |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Male
medicine.medical_specialty medicine.drug_class medicine.medical_treatment Narcotic Antagonists Biology Handling Psychological Basal (phylogenetics) chemistry.chemical_compound Developmental Neuroscience Naltrindole Corticosterone Stress Physiological Internal medicine Receptors Opioid delta medicine Animals Rats Wistar Receptor Saline Swimming Sex Characteristics Temperature Water Radioimmunoassay Naltrexone Animals Suckling Rats Endocrinology chemistry Adrenal Cortex Female Opioid antagonist Developmental Biology medicine.drug Hormone |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| ISSN: | 0165-3806 |
| Popis: | The effect of a daily injection of the δ-selective opioid antagonist naltrindole (1 mg/kg), from birth to postnatal day 19, on basal and post- stress corticosterone levels in 25-day old rats of both sexes was investigated. The effects of manipulation were studied by including two control groups, one group received daily injections of saline and a second one was not manipulated. The stress protocol consisted of a 3 min swimming session in water at 20°C. Corticosterone determinations were performed by radioimmunoassay. Control non-manipulated animals showed a significant increase in corticosterone levels in response to stress. Manipulation decreased basal hormone levels in females and prevented the stress-induced rise in corticosterone in males. Functional blockade of the δ-receptor during the preweanling period by the naltrindole treatment inhibited the corticosterone response to stress in females. The results indicate the existence of sex differences in the effects of manipulation on hypothalamus- pituitary-adrenal axis activity and the involvement of the δ-opioid receptor in the modulation of the adrenocortical response to stress during the postnatal period. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect