Malaria causes long-term effects on markers of iron status in children:a critical assessment of existing clinical and epidemiological tools
| Autor: | N. O. Opoku, Bjarne Styrishave, Jørgen A. L. Kurtzhals, Michael F. Ofori, Kwadwo A. Koram, Edem W. Sarbah, Lars Hviid, Filip C. Castberg |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Fibroblast growth factor 23
Male Hepcidin Cohort Studies 0302 clinical medicine FGF23 Epidemiology 030212 general & internal medicine Malaria Falciparum Child media_common biology Convalescence Iron deficiency Iron Deficiencies Infectious Diseases Child Preschool Female medicine.medical_specialty lcsh:Arctic medicine. Tropical medicine lcsh:RC955-962 media_common.quotation_subject Iron 030231 tropical medicine lcsh:Infectious and parasitic diseases 03 medical and health sciences Hepcidins Internal medicine parasitic diseases medicine Humans lcsh:RC109-216 Inflammation Ferritin business.industry Research C-reactive protein Infant medicine.disease Malaria Fibroblast Growth Factors Fibroblast Growth Factor-23 Ferritins biology.protein Parasitology business Deficiency Diseases Biomarkers |
| Zdroj: | Castberg, F C, Sarbah, E W, Koram, K A, Opoku, N, Ofori, M F, Styrishave, B, Hviid, L & Kurtzhals, J A L 2018, ' Malaria causes long-term effects on markers of iron status in children : a critical assessment of existing clinical and epidemiological tools ', Malaria Journal, vol. 17, no. 1, 464 . https://doi.org/10.1186/s12936-018-2609-6 Malaria Journal, Vol 17, Iss 1, Pp 1-12 (2018) Malaria Journal |
| DOI: | 10.1186/s12936-018-2609-6 |
| Popis: | BackgroundMost epidemiological studies on the interplay between iron deficiency and malaria risk classify individuals as iron-deficient or iron-replete based on inflammation-dependent iron markers and adjustment for inflammation by using C-reactive protein (CRP) or α-1-acid glycoprotein (AGP). The validity of this approach and the usefulness of fibroblast growth factor 23 (FGF23) as a proposed inflammation-independent iron marker were tested.MethodsConventional iron markers and FGF23 were measured in children with acute falciparum malaria and after 1, 2, 4, and 6 weeks. Children, who were transfused or received iron supplementation in the follow-up period, were excluded, and iron stores were considered to be stable throughout. Ferritin levels 6 weeks after admission were used as a reference for admission iron status and compared with iron markers at different time points.ResultsThere were long-term perturbations in iron markers during convalescence from acute malaria. None of the tested iron parameters, including FGF23, were independent of inflammation. CRP and AGP normalized faster than ferritin after malaria episodes.ConclusionMalaria may bias epidemiological studies based on inflammation-dependent iron markers. Better markers of iron status during and after inflammation are needed in order to test strategies for iron supplementation in populations at risk of malaria. |
| Databáze: | OpenAIRE |
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