Halogenated Chrysins Inhibit Dengue and Zika Virus Infectivity
| Autor: | Wanchalerm Yuttithamnon, Krongkan Kingkaew, Siwaporn Boonyasuppayakorn, Warinthorn Chavasiri, Saran Pankaew, Pimsiri Srivarangkul, Aphinya Suroengrit |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Cell Survival lcsh:Medicine Drug action Biology Dengue virus medicine.disease_cause Antiviral Agents Article Cell Line Dengue fever Zika virus Dengue 03 medical and health sciences chemistry.chemical_compound Chlorocebus aethiops medicine Animals Humans Potency Chrysin lcsh:Science EC50 Infectivity Multidisciplinary Dose-Response Relationship Drug Molecular Structure Zika Virus Infection lcsh:R Zika Virus Dengue Virus Flavones medicine.disease biology.organism_classification Macaca mulatta Virology 030104 developmental biology chemistry lcsh:Q |
| Zdroj: | Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017) Scientific Reports |
| ISSN: | 2045-2322 |
| Popis: | Dengue virus infection is a global threat for which no specific treatment has not been established. Previous reports suggested chrysin and flavanone derivatives were potential flaviviral inhibitors. Here, we reported two halogenated chrysins, abbreviated FV13 and FV14, were highly potent against DENV1-4 and ZIKV infectivities with the FV13 EC50 values of 2.30 ± 1.04, 1.47 ± 0.86, 2.32 ± 1.46, 1.78 ± 0.72 and 1.65 ± 0.86 µM; and FV14 EC50 values of 2.30 ± 0.92, 2.19 ± 0.31, 1.02 ± 0.31, 1.29 ± 0.60 and 1.39 ± 0.11 µM, respectively. The CC50s to LLC/MK2 of FV13 and FV14 were 44.28 ± 2.90 μM, 42.51 ± 2.53 µM, respectively. Mechanism of drug action studies suggested multiple targets but maximal efficiency was achieved with early post infection treatment. This is the first report showing a high potency of halogenated chrysins for development as a broad-spectrum anti-flaviviral drug. |
| Databáze: | OpenAIRE |
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