The effect of the benzodiazepine antagonist flumazenil on regional cerebral blood flow in human volunteers
| Autor: | P. B. Hansen, Lars Friberg, J. Wolff, Jan Skov Jensen, Niels A. Lassen, Allan R. Andersen |
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| Rok vydání: | 1990 |
| Předmět: |
Adult
Flumazenil Male medicine.drug_class Hemodynamics Blood Pressure Placebos Cerebral circulation Double-Blind Method mental disorders medicine Humans Tomography Emission-Computed Single-Photon Benzodiazepine business.industry Antagonist Brain General Medicine Carbon Dioxide nervous system diseases Anesthesiology and Pain Medicine Blood pressure nervous system Cerebral blood flow Cerebrovascular Circulation Anesthesia Injections Intravenous Arterial blood Female business Xenon Radioisotopes psychological phenomena and processes circulatory and respiratory physiology medicine.drug |
| Zdroj: | Acta Anaesthesiologica Scandinavica. 34:628-631 |
| ISSN: | 1399-6576 0001-5172 |
| DOI: | 10.1111/j.1399-6576.1990.tb03160.x |
| Popis: | The influence of the benzodiazepine antagonist flumazenil on regional cerebral blood flow (rCBF) was investigated in ten healthy, alert volunteers. The design was a randomized, placebo-controlled, double-blind, cross-over study. rCBF was measured by 133-Xe inhalation and single photon emission computerized tomography, SPECT, immediately before, and 5 and 35 min after intravenous injection of flumazenil 1.0 mg or placebo. In addition, mean arterial blood pressure and Paco2 were measured. There were no significant differences in the mean arterial blood pressures or Paco2. rCBF were analysed for changes in various regions of interest (RoI). No alterations were found either in the global CBF or in rCBF in RoI after flumazenil injection. The results showed that a clinically active dose of flumazenil did not directly affect the cerebral circulation in the normal brain and indicated absence of significant intrinsic activity of the drug. |
| Databáze: | OpenAIRE |
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