Characterization of gammadelta T cells expressing CD158b, a killer cell inhibitory receptor, in a patient with chronic CD4(+) lymphocytopenia and disseminated Mycobacterium intracellulare infection
| Autor: | C. M. Antonioli, S. Licenziati, Luisa Imberti, Fabio Malacarne, Arnaldo Caruso, Roberto Stellini, Alberto Albertini, Paolo Airò, Roberto Cattaneo |
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| Rok vydání: | 2000 |
| Předmět: |
Cytotoxicity
Immunologic T cell Lymphocyte CD8 Antigens Immunology Macrophage-1 Antigen chemical and pharmacologic phenomena Apoptosis Biology Immunophenotyping Antigen CD28 Antigens Receptors KIR Antigens CD medicine Cell Adhesion Immunology and Allergy Cytotoxic T cell Humans Receptors Immunologic T-Lymphocytopenia Idiopathic CD4-Positive Mycobacterium avium-intracellulare Infection CD28 hemic and immune systems Receptors Antigen T-Cell gamma-delta T lymphocyte Middle Aged medicine.disease Mycobacterium avium Complex Killer Cells Natural medicine.anatomical_structure Receptors KIR2DL3 Chronic Disease Female Endothelium Vascular Lymphocytopenia CD8 Cell Division |
| Zdroj: | Clinical immunology (Orlando, Fla.). 96(1) |
| ISSN: | 1521-6616 |
| Popis: | A population of Vdelta1(+)Vgamma9(-) gammadelta T cells that represented almost the totality (84%) of circulating lymphocytes in a patient with chronic, non-HIV-related, CD4 lymphocytopenia complicated by a disseminated Mycobacterium intracellulare infection was characterized. These gammadelta(+) T cells expressed a single killer inhibitory receptor (CD158b) and their phenotype (CD8(+)CD57(+)CD27(-)CD28(-)) indicated that, although CD45RA(+), they were not naive. However, the absence of large granular lymphocyte morphology, the impaired proliferative activity, the high susceptibility to apoptosis, and the total lack of cytotoxic ability suggested that these gammadelta cells were in a resting state. A high percentage of the cells did not harbor the CD11b integrin alpha chain and exhibited a decreased capability to bind endothelial cells. This defect might represent the mechanism whereby they remained trapped in the circulation. |
| Databáze: | OpenAIRE |
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