Fatty Acids and Immune Function: Relevance to Inflammatory Bowel Diseases

Autor:	Phillip C. Calder
Rok vydání:	2009
Předmět:	T-Lymphocytes Immunology Inflammation Models Biological chemistry.chemical_compound Immune system Fatty Acids Omega-3 medicine Animals Humans Immunology and Allergy adipocyte protein 2 Molecular Structure biology Fatty Acids Immunity Inflammatory Bowel Diseases Fish oil Eicosapentaenoic acid chemistry Biochemistry Eicosanoid Docosahexaenoic acid biology.protein Arachidonic acid sense organs medicine.symptom
Zdroj:	International Reviews of Immunology. 28:506-534
ISSN:	1563-5244 0883-0185
DOI:	10.3109/08830180903197480
Popis:	Fatty acids may influence immune function through a variety of mechanisms; many of these are associated with changes in fatty acid composition of immune cell membranes. Eicosanoids produced from arachidonic acid have roles in inflammation and immunity. Increased membrane content of n-3 fatty acids results in a changed pattern of production of eicosanoids, resolvins, and cytokines. Changing the fatty acid composition of immune cells also affects T cell reactivity and antigen presentation. Little attention has been paid to the influence of fatty acids on the gut-associated lymphoid tissue. However, there has been considerable interest in fatty acids and gut inflammation.
Databáze:	OpenAIRE
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