A molecular propeller effect for chiral separation and analysis
| Autor: | Jonathon B. Clemens, Mirianas Chachisvilis, Osman Kibar |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Rotation
Field (physics) General Physics and Astronomy 02 engineering and technology Molecular propeller 010402 general chemistry 01 natural sciences Molecular physics Article General Biochemistry Genetics and Molecular Biology Electricity Circular polarization Multidisciplinary Rotation around a fixed axis Absolute configuration Analytic Sample Preparation Methods Stereoisomerism General Chemistry 021001 nanoscience & nanotechnology 0104 chemical sciences 3. Good health Solutions Classical mechanics Erratum Enantiomer 0210 nano-technology Chirality (chemistry) |
| Zdroj: | Nature Communications |
| ISSN: | 2041-1723 |
| Popis: | Enantiomers share nearly identical physical properties but have different chiral geometries, making their identification and separation difficult. Here we show that when exposed to a rotating electric field, the left- and right-handed chiral molecules rotate with the field and act as microscopic propellers; moreover, owing to their opposite handedness, they propel along the axis of field rotation in opposite directions. We introduce a new molecular parameter called hydrodynamic chirality to characterize the coupling of rotational motion of a chiral molecule into its translational motion and quantify the direction and velocity of such motion. We demonstrate >80% enrichment level of counterpart enantiomers in solution without using chiral selectors or circularly polarized light. We expect our results to have an impact on multiple applications in drug discovery, analytical and chiral chemistry, including determination of absolute configuration, as well as in influencing the understanding of artificial and natural molecular systems where rotational motion of the molecules is involved. Separation and analysis of enantiomers is a difficult task due to the normally identical physical properties they display. Here, the authors show how chiral molecules with non-zero dipoles can be propelled in opposite directions under the influence of a rotating electric field. |
| Databáze: | OpenAIRE |
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