Increased glutathione peroxidase activity in alpha-thalassemia
| Autor: | E Beutler, Jane Warner, F Matsumoto, D Powars |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
chemistry.chemical_classification
medicine.medical_specialty congenital hereditary and neonatal diseases and abnormalities Red Cell Chemistry Glutathione peroxidase Immunology Alpha-thalassemia Cell Biology Hematology medicine.disease Glutathione peroxidase activity Biochemistry Endocrinology Internal medicine hemic and lymphatic diseases medicine Hemoglobin H Disease |
| Zdroj: | Blood. 50:647-655 |
| ISSN: | 1528-0020 0006-4971 |
| DOI: | 10.1182/blood.v50.4.647.bloodjournal504647 |
| Popis: | Glutathione peroxidase (GSHPx) activity was found to be greatly elevated in members of a family with alpha-thalassemia. Eleven other families with proven alpha-thalassemia were investigated, and all but one subject with hemoglobin H disease had increased red cell GSHPx. Most persons with alpha-thalassemia trait also had increased activity of red cell GSHPx. In contrast, only very modest increases in glutathione peroxidase activity were observed in subjects with various forms of beta-thalassemia. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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