Alteration of serum levels of inflammatory cytokines and polysomnographic indices after uvulopalatal flap surgery in obstructive sleep apnea
| Autor: | Istemihan Akin, Murad Mutlu, Sadik Ardic, Ece Miser, Erkan Vuralkan, Sevgi Akaydin, Hikmet Firat |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Polysomnography 030204 cardiovascular system & hematology Severity of Illness Index Surgical Flaps Proinflammatory cytokine 03 medical and health sciences 0302 clinical medicine Severity of illness medicine Humans Postoperative Period Cystatin C Oxygen saturation (medicine) Sleep Apnea Obstructive biology business.industry Palate Tumor Necrosis Factor-alpha Sleep apnea Middle Aged medicine.disease Intercellular Adhesion Molecule-1 Surgery Obstructive sleep apnea C-Reactive Protein Treatment Outcome Otorhinolaryngology Apnea–hypopnea index Uvula Preoperative Period biology.protein Cytokines Female Cystatin business 030217 neurology & neurosurgery |
| Zdroj: | Ear, nose,throat journal. 96(2) |
| ISSN: | 1942-7522 |
| Popis: | © 2016 Vendome Group, LLC All rights reserved.The aim of the current study was to compare the changes in polysomnographic indices and serum levels of C-reactive protein (CRP), cystatin C, tumor necrosis factor-α (TNF-α), and intercellular adhesion molecule-1 (ICAM-1) in patients with obstructive sleep apnea (OSA) who were treated surgically via a uvulopalatal flap (UPF) technique. Twenty-five patients (14 men, 11 women), average age 46.2 ± 9.3 years, who underwent UPF surgery were included in this study. Serum biochemical analyses and polysomnographic examinations were performed before and 6 months after the surgery. Pre- and postoperative values of apnea hypopnea index (AHI), oxygen desaturation index (ODI), and minimum oxygen concentrations, as well as serum levels of CRP, cystatin C, TNF-α, and ICAM-1 were compared. Comparison of variables before and after UPF surgery demonstrated that AHI (p = 0.001), ODI (p < 0.001) and oxygen saturation (p < 0.001) were significantly improved. In addition, serum levels of CRP (p = 0.036), cystatin C (p = 0.005), TNF-α (p < 0.001), and ICAM-1 (p < 0.001) were significantly reduced 6 months after surgery. Our results suggest that UPF is an effective surgical method that alleviates the severity of OSA. Moreover, it may have the potential to prevent the development of atherosclerosis by attenuating the inflammatory process induced by activation of inflammatory mediators such as CRP, TNF-α, ICAM-1, and cystatin C. |
| Databáze: | OpenAIRE |
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