Association between the non-HDL-cholesterol to HDL-cholesterol ratio and non-alcoholic fatty liver disease in Chinese children and adolescents: a large single-center cross-sectional study

Autor:	Guang-Rong Lu, Jinwei Zhong, Xinhe Zhou, Shou-Xing Yang, Changlong Xu, Lei Miao, Zhan-Xiong Xue, Mengsi Ye
Rok vydání:	2020
Předmět:	Blood Glucose Male medicine.medical_specialty China Adolescent Clinical chemistry Cross-sectional study Endocrinology Diabetes and Metabolism Clinical Biochemistry 030209 endocrinology & metabolism Clinical nutrition 030204 cardiovascular system & hematology Single Center Adolescents Body Mass Index 03 medical and health sciences 0302 clinical medicine Endocrinology Non-alcoholic Fatty Liver Disease Internal medicine medicine Humans Obesity Child Children Receiver operating characteristic curve Ultrasonography Receiver operating characteristic Anthropometry business.industry Research Biochemistry (medical) Fatty liver Cholesterol HDL Alanine Transaminase medicine.disease Uric Acid NHDLC/HDLC ratio Liver Female Insulin Resistance business Lipidology
Zdroj:	Lipids in Health and Disease
ISSN:	1476-511X
Popis:	Background The non-HDL-cholesterol to HDL-cholesterol (NHDLC/HDLC) ratio is closely related to a variety of dyslipidemia-related diseases. This study examined the relationship between the NHDLC/HDLC ratio and non-alcoholic fatty liver (NAFLD) in children and adolescents. Methods This cross-sectional survey included a total of 7759 eligible Chinese children and adolescents (5692 boys and 2067 girls) who received routine medical examinations. The anthropometric and laboratory data of the subjects were collected. NAFLD was diagnosed by liver ultrasonography. Binary logistic regression analysis was performed on the NHDLC/HDLC ratio, NHDLC, HDLC and NAFLD. Receiver operating characteristic (ROC) curve analysis was used to compare the diagnostic significance of the above parameters for NAFLD. Results The total prevalence of NAFLD was 4.36%, and the prevalence in boys was higher than that in girls (5.61% vs. 1.9%, P P P P = 0.035) was still significantly higher than that of tertile 1. The area under the curve (AUC) of the NHDLC/HDLC ratio of boys was 0.787, which was significantly greater than NHDLC and HDLC (0.719 and 0.726, P P P P = 0.007). For subjects with elevated ALT levels (ALT > 40 U/L), the AUC of the NHDLC/HDLC ratio (0.746) was also significantly greater than NHDLC (0.646, P Conclusions The NHDLC/HDLC ratio was positively correlated with NAFLD in Chinese children and adolescents. It may serve as an effective indicator to help identify NAFLD in children and adolescents.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11ca19efcb5bb18418de9f39bbb9d213 https://pubmed.ncbi.nlm.nih.gov/33222696 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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