Long-term effects of growth hormone on infarct size and left ventricular function in sheep with coronary artery occlusion
| Autor: | Rubén P. Laguens, Alberto J. Crottogini, Patricia Cabeza Meckert, J. G. Barra, Andrea De Lorenzi, Claudia Cortés, Andrés Bercovich, Oscar Cendoya, Eliseo González, Fernanda Daniela Olea |
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| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty CIENCIAS MÉDICAS Y DE LA SALUD Time Factors medicine.medical_treatment Injections Subcutaneous Cardiac index Myocardial Infarction Medicina Clínica Placebo Growth hormone Ventricular Function Left ACUTE MYOCARDIAL INFARCTION Contractility Internal medicine medicine Animals Myocardial infarction Insulin-Like Growth Factor I Pharmacology Sheep Ventricular function Sistemas Cardíaco y Cardiovascular Dose-Response Relationship Drug business.industry Human Growth Hormone Growth factor INFARCT SIZE Infarct size medicine.disease Disease Models Animal Endocrinology SHEEP Coronary Occlusion Cardiology GROWTH HORMONE Cardiology and Cardiovascular Medicine business |
| Zdroj: | Journal of cardiovascular pharmacology. 55(3) |
| ISSN: | 1533-4023 |
| Popis: | The effects of growth hormone (GH) on infarct size and left ventricular (LV) function in experimental acute myocardial infarction (AMI) have been controversial. Moreover, little, if any, information exists regarding long-term evaluation of therapeutic doses of GH in large mammalian models of AMI. We therefore aimed to assess the effect of therapeutic doses of GH over 3.5 months on infarct size and heart function in sheep with AMI. After coronary artery ligation, sheep received subcutaneous human GH 8 IU/d (n = 8) or vehicle (n = 8) over 100 days. Infarct area was similar in GH (16.9% 6 3% of LV area) and placebo (16.5% 6 3.7%, P = not significant) sheep. At 3 days of treatment onset, but not at later times, GH sheep had higher LV shortening fraction (30.7% 6 3.5% vs. 24.8% 6 6.1%, P , 0.04), systolic anterior wall thickness (10.1 6 0.8 vs. 8.6 6 1.2 mm, P , 0.02), and cardiac index (3.8 6 0.6 vs. 2.8 6 0.7 L min21 m22 , P , 0.01). This evolution of function parameters paralleled that of serum insulin-like growth factor 1 levels, which differed significantly only during the first week, suggesting a direct effect of GH on LV contractility. These results may suggest the usefulness of therapeutic doses of GH at the early phases of AMI but do not support maintaining the treatment for longer time. Fil: Olea, Fernanda Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina Fil: De Lorenzi, Andrea. Universidad Favaloro; Argentina Fil: Cortés, Claudia. Universidad Favaloro; Argentina Fil: Cabeza Meckert, Patricia. Universidad Favaloro; Argentina Fil: Cendoya, Oscar. Universidad Favaloro; Argentina Fil: Barra, Juan G.. Universidad Favaloro; Argentina Fil: Bercovich, Andrés. Biosidus S. A.; Argentina Fil: González, Eliseo. Biosidus S. A.; Argentina Fil: Laguens, Rubén. Universidad Favaloro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Crottogini, Alberto José. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina |
| Databáze: | OpenAIRE |
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