Skeletal muscle involvement in patients with chronic alcoholic intoxication
| Autor: | N. S. Shcheglova, Boris Shenkman, O. E. Zinovyeva, E G Altayeva, Y. V. Kazantseva |
|---|---|
| Jazyk: | ruština |
| Rok vydání: | 2013 |
| Předmět: |
Pathology
medicine.medical_specialty protein synthesis diagnosis Disease chronic alcoholic myopathy Pathogenesis Internal medicine medicine Myopathy RC346-429 Muscle biopsy medicine.diagnostic_test business.industry Chronic alcoholic Skeletal muscle insulin-growth-like growth factor 1 Psychiatry and Mental health Clinical Psychology Endocrinology medicine.anatomical_structure Neurology (clinical) Neurology. Diseases of the nervous system medicine.symptom muscle biopsy business Intracellular |
| Zdroj: | Nevrologiâ, Nejropsihiatriâ, Psihosomatika, Vol 5, Iss 1, Pp 39-42 (2013) |
| ISSN: | 2310-1342 2074-2711 |
| Popis: | Chronic alcoholic myopathy (CAM) is a common manifestation of alcoholic disease; however, the pathogenesis of the former has not been fully investigated. The main mechanism for the development of CAM is postulated to be impaired protein synthesis in the muscle fibers. A comprehensive clinical, biochemical, electromyographic, and morphological examination was made in 51 patients with chronic alcoholic intoxication. Morphological and morphometric studies were shown to play a determining role in the diagnosis of CAM. The clinical manifestations of skeletal muscle involvement corresponded to the magnitude of the atrophic process. Abnormalities were found in the basic components of protein synthesis at both the intracellular and systemic levels of regulation. |
| Databáze: | OpenAIRE |
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