| Autor: |
Bejar, Cynthia A., Goyal, Shiwali, Afzal, Shoaib, Mangino, Massimo, Zhou, Ang, van der Most, Peter J., Bao, Yanchun, Gupta, Vipin, Smart, Melissa C., Walia, Gagandeep K., Verweij, Niek, Power, Christine, Prabhakaran, Dorairaj, Singh, Jai Rup, Mehra, Narinder K., Wander, Gurpreet S., Ralhan, Sarju, Kinra, Sanjay, Kumari, Meena, de Borst, Martin H., Hyppönen, Elina, Spector, Tim D., Nordestgaard, Børge G., Blackett, Piers R., Sanghera, Dharambir K. |
| Rok vydání: |
2021 |
| DOI: |
10.6084/m9.figshare.15064129.v1 |
| Popis: |
Additional file 1: Supplementary Table 1. Association results of individual T2D SNPs used as genetic instruments in Mendelian randomization for their association with T2D. Supplementary Table 2. Association of individual T2D SNPs used as genetic instruments in Mendelian randomization analyses for their association with 25(OH)D concentrations. Supplementary Table 3. Association results of individual vitamin D SNPs used as genetic instruments in Mendelian randomization for their association with circulating 25(OH)D concentration. Supplementary Table 4. Association results of individual vitamin D SNPs used as genetic instruments in Mendelian randomization for their association with T2D. Supplementary Table 5. Association of vitamin D SNPs used as genetic instruments for affecting 25(OH)D concentrations using UV index as a covariate. Supplementary Table 6. Association of vitamin D SNPs used as genetic instruments showing their effect on Type 2 diabetes risk using UV index as a covariate. Supplementary Table 7 A-B. Results of joint metanalysis of current study and a published study (Lu et al, 2018) showing significant associations of variants in vitamin D candidate genes (GC and DHCR7) for effecting 25(OH)D concentrations. Supplementary Table 8 A-B. Results of joint metanalysis of current study and a published study (Lu et al, 2018) showing effects of genetically instrumented vitamin D candidate genes (GC and DHCR7) SNPs for their effects on T2D risk. Supplementary Table 9. Information on samples with missing 25(OH)D levels from 8 different cohorts. Supplementary Table 10. Differences in latitude, 25(OH)D concentration and distribution of allele frequencies of vitamin D and T2D SNPs among South Asian and European cohorts. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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