Involvement of cortical fast-spiking parvalbumin-positive basket cells in epilepsy
| Autor: | Xiao Jiang, Elsa Rossignol, Mathieu Lachance |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Cerebral Cortex Epilepsy biology Action Potentials Stimulation medicine.disease Article Transplantation 03 medical and health sciences Synaptic function 030104 developmental biology medicine.anatomical_structure Parvalbumins Cortical network Cerebral cortex Interneurons biology.protein medicine GABAergic Animals Humans Neuroscience Parvalbumin |
| Zdroj: | Progress in brain research. 226 |
| ISSN: | 1875-7855 |
| Popis: | GABAergic interneurons of the parvalbumin-positive fast-spiking basket cells subtype (PV INs) are important regulators of cortical network excitability and of gamma oscillations, involved in signal processing and cognition. Impaired development or function of PV INs has been associated with epilepsy in various animal models of epilepsy, as well as in some genetic forms of epilepsy in humans. In this review, we provide an overview of some of the experimental data linking PV INs dysfunction with epilepsy, focusing on disorders of the specification, migration, maturation, synaptic function, or connectivity of PV INs. Furthermore, we reflect on the potential therapeutic use of cell-type specific stimulation of PV INs within active networks and on the transplantation of PV INs precursors in the treatment of epilepsy and its comorbidities. |
| Databáze: | OpenAIRE |
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