BMP Implant Associated with Platelet-Rich Plasma in Orbit Fracture Repair

Autor:	Claudia H. Pellizon, Silvana Artioli Schellini, Flavio E. Hirai, Fabio H. Ferraz, Carlos Roberto Padovani, Ricardo de Campos Schellini
Rok vydání:	2008
Předmět:	Male medicine.medical_specialty Pathology Bone morphogenetic protein Osseointegration Cellular and Molecular Neuroscience Osteogenesis medicine Animals Bone regeneration Orbital Fracture Orbital Fractures Wound Healing Bone Transplantation Platelet-Rich Plasma Ossification business.industry Combined Modality Therapy Sensory Systems Surgery Radiography Disease Models Animal Ophthalmology Platelet-rich plasma Bone Morphogenetic Proteins Intramembranous ossification Rabbits Implant medicine.symptom business Orbit
Zdroj:	Current Eye Research. 33:293-301
ISSN:	1460-2202 0271-3683
DOI:	10.1080/02713680801892020
Popis:	To evaluate a bone morphogenetic protein (BMP) implant with and without platelet-rich plasma (PRP), which is supposed to accelerate fracture consolidation in the orbit fracture treatment.Thirty-six white rabbits were subjected to orbital fracture and treated in three groups: BMP implant fracture repair (G1), BMP plus PRP implant fracture repair (G2), and fracture and spontaneous repair (G3). The animals were sacrificed at 7, 30, 90, and 180 days after surgery. A radiology evaluation was carried out on the 7th day after the fracture and at the sacrifice moments. After the animals' death, the orbital content material was removed and prepared for morphological and morphometric analysis.Radiology suggested intramembranous and progressive cavitation and ossification without a reduction in implant size and with signs of calcium deposition; these events were confirmed by histological analysis, which showed a lymphomononuclear inflammatory reaction in G1 and G2, more intense 7 days after surgery and reducing after 30 days. Associating PRP with BMP did not accelerate bone induction.BMP implant promotes bone induction, integration at fracture site, scarce inflammatory reaction, and may be a good alternative in orbit fracture reconstruction. The addition of PRP to the BMP plate did not accelerate the resolution, and its use is not necessary.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11bfd86202b3c9b2ff7125a1adbf86c5 https://doi.org/10.1080/02713680801892020 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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