Interactive effects of neonatal exposure to monosodium glutamate and aspartame on glucose homeostasis
| Autor: | Kate S. Collison, Mohammed Shoukri, Angela Inglis, Nadine J. Makhoul, Bernard Andres, Marya Z. Zaidi, Rosario Ubungen, Futwan Al-Mohanna, Rana Al-Rabiah |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Monosodium glutamate Endocrinology Diabetes and Metabolism medicine.medical_treatment Medicine (miscellaneous) lcsh:TX341-641 chemistry.chemical_compound Insulin resistance Internal medicine medicine Glucose homeostasis Aspartame lcsh:RC620-627 Monosodium Glutamate Nutrition and Dietetics business.industry Research Insulin Weight change Insulin tolerance test Insulin tolerance medicine.disease Impaired fasting glucose lcsh:Nutritional diseases. Deficiency diseases Endocrinology chemistry business lcsh:Nutrition. Foods and food supply |
| Zdroj: | Nutrition & Metabolism, Vol 9, Iss 1, p 58 (2012) Nutrition & Metabolism |
| ISSN: | 1743-7075 |
| Popis: | Background Recent evidence suggests that the effects of certain food additives may be synergistic or additive. Aspartame (ASP) and Monosodium Glutamate (MSG) are ubiquitous food additives with a common moiety: both contain acidic amino acids which can act as neurotransmitters, interacting with NMDA receptors concentrated in areas of the Central Nervous System regulating energy expenditure and conservation. MSG has been shown to promote a neuroendocrine dysfunction when large quantities are administered to mammals during the neonatal period. ASP is a low-calorie dipeptide sweetener found in a wide variety of diet beverages and foods. However, recent reports suggest that ASP may promote weight gain and hyperglycemia in a zebrafish nutritional model. Methods We investigated the effects of ASP, MSG or a combination of both on glucose and insulin homeostasis, weight change and adiposity, in C57BL/6 J mice chronically exposed to these food additives commencing in-utero, compared to an additive-free diet. Pearson correlation analysis was used to investigate the associations between body characteristics and variables in glucose and insulin homeostasis. Results ASP alone (50 mg/Kgbw/day) caused an increase in fasting blood glucose of 1.6-fold, together with reduced insulin sensitivity during an Insulin Tolerance Test (ITT) P Conclusions Aspartame exposure may promote hyperglycemia and insulin intolerance. MSG may interact with aspartame to further impair glucose homeostasis. This is the first study to ascertain the hyperglycemic effects of chronic exposure to a combination of these commonly consumed food additives; however these observations are limited to a C57BL/6 J mouse model. Caution should be applied in extrapolating these findings to other species. |
| Databáze: | OpenAIRE |
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