Interleukin 18 (IL-18) upregulation in acute rejection of kidney allograft
| Autor: | Ilja, Striz, Eliska, Krasna, Krasna, Eliska, Eva, Honsova, Honsova, Eva, Jiri, Lacha, Lacha, Jiri, Katerina, Petrickova, Petrickova, Katerina, Marcela, Jaresova, Jaresova, Marcela, Alena, Lodererova, Lodererova, Alena, Radka, Bohmova, Bohmova, Radka, Sarka, Valhova, Valhova, Sarka, Antonij, Slavcev, Slavcev, Antonij, Stefan, Vitko, Vitko, Stefan |
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| Rok vydání: | 2005 |
| Předmět: |
Graft Rejection
Pathology medicine.medical_specialty Biopsy Immunology Kidney Cell Line Proinflammatory cytokine Interferon-gamma Immune system medicine Humans Transplantation Homologous Immunology and Allergy Kidney surgery Kidney transplantation business.industry Interleukin-18 Kidney metabolism Epithelial Cells medicine.disease Immunohistochemistry Kidney Transplantation Up-Regulation Transplantation medicine.anatomical_structure RNA Interleukin 18 business |
| Zdroj: | Immunology Letters. 99:30-35 |
| ISSN: | 0165-2478 |
| DOI: | 10.1016/j.imlet.2005.01.010 |
| Popis: | Interleukin 18 (IL-18) is a potent proinflammatory cytokine involved in the host defence by upregulating both innate and acquired immune responses and may be of particular importance also in mechanisms of kidney allograft rejection. Immunohistochemical staining of protocol biopsies showed constitutive IL-18 expression in the epithelium of distal tubules with the induction of immunoreactivity in acute rejection patients where also proximal tubules, infiltrating leukocytes, and endothelium were strongly positive. Furthermore, serum levels of IL-18 were significantly elevated in patients with acute rejection of kidney allograft (1247+/-389 pg/l) as compared to patients with uncomplicated outcome of kidney transplantation (444+/-164 pg/l) and subjects with acute tubulointerstitial nephropathy (385+/-155 pg/l, p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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