Structural network maturation of the preterm human brain
| Autor: | Lina F. Chalak, Virendra Mishra, Jessica L. Wisnowski, Tengda Zhao, Qinmu Peng, Hao Huang, Nancy K. Rollins, Tina Jeon, Ni Shu, Roy J. Heyne, Minhui Ouyang |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Nerve net Cognitive Neuroscience Precuneus Biology Brain mapping 3rd trimester Article 050105 experimental psychology 03 medical and health sciences 0302 clinical medicine Posterior cingulate gyrus medicine Biological neural network Humans 0501 psychology and cognitive sciences Brain function Brain Mapping 05 social sciences Infant Newborn Brain Anatomy Human brain Structural connectome Diffusion Magnetic Resonance Imaging medicine.anatomical_structure Neurology Connectome Female Nerve Net Neuroscience Infant Premature 030217 neurology & neurosurgery Diffusion MRI |
| Zdroj: | NeuroImage. 185:699-710 |
| ISSN: | 1053-8119 |
| Popis: | During the 3rd trimester, large-scale of neural circuits are formed in the human brain, resulting in the adult-like brain networks at birth. However, how the brain circuits develop into a highly efficient and segregated connectome during this period is unknown. We hypothesized that faster increases of connectivity efficiency and strength at the brain hubs and rich-club are critical for emergence of an efficient and segregated brain connectome. Here, using high resolution diffusion MRI of 77 preterm-born and term-born neonates scanned at 31-42 postmenstrual weeks (PMW), we constructed the structural connectivity matrices and performed graph-theory-based analyses. We found faster increases of nodal efficiency mainly at the brain hubs, distributed in primary sensorimotor regions, superior-middle frontal and posterior cingulate gyrus during 31-42PMW. The rich-club and within-module connections were characterized by higher rates of edge strength increases. Edge strength of short-range connections increased faster than that of long-range connections. The nodal efficiencies of the hubs predicted individual postmenstrual ages more accurately than those of non-hubs. Collectively, these findings revealed regionally differentiated maturation in the baby brain structural connectome and more rapid increases of the hub and rich-club connections, which underlie network segregation and differentiated brain function emergence. |
| Databáze: | OpenAIRE |
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