Quinidine oxidative metabolism. Identification and biosynthesis of quinidine 10,11-dihydrodiol stereoisomers
| Autor: | R. Leroyer, O. Varoquaux, M. Pays, Charles Advenier |
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| Rok vydání: | 1990 |
| Předmět: |
Male
Quinidine Clinical Biochemistry Stereoisomerism Biochemistry Gas Chromatography-Mass Spectrometry Analytical Chemistry Cyclic N-Oxides chemistry.chemical_compound Biosynthesis Drug Discovery medicine Animals Bile Humans Secretion Molecular Biology Chromatography High Pressure Liquid Pharmacology Chromatography Molecular Structure Quinine Chemistry Rats Inbred Strains General Medicine Rats medicine.anatomical_structure Liver Phenobarbital Hepatocyte Gas chromatography Gas chromatography–mass spectrometry medicine.drug |
| Zdroj: | Biomedical Chromatography. 4:61-64 |
| ISSN: | 1099-0801 0269-3879 |
| DOI: | 10.1002/bmc.1130040205 |
| Popis: | The isocratic reversed phase high performance liquid chromatographic method proposed for quinidine metabolic studies facilitates particularly the separation of 10(R) and (S) isomers of quinidine 10,11-dihydrodiols. The finding of each of these forms following a new synthetic pathway allows us to identify and quantify them in biological fluids. These two isomers have especially been observed in rat bile and hepatocyte secretions. The metabolic inducing effect of phenobarbital on the oxidative metabolism of quinidine is verified in rat isolated hepatocytes. Simultaneous secretion of the two dihydrodiols is also verified in human urine by a gas chromatography/mass spectrometry procedure. |
| Databáze: | OpenAIRE |
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