Postnatal functional inactivation of the ventral subiculum enhances dopaminergic responses in the core part of the nucleus accumbens following ketamine injection in adult rats

Autor: Séverine Eybrard, Hana Saoud, Alain Louilot, Duco De Beus
Přispěvatelé: Neuropsychologie Cognitive et Physiopathologie de la Schizophrénie (NCPS), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Civil de Strasbourg, Faculty of Medicine-ULP, LOUILOT, Alain
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Male
[SDV]Life Sciences [q-bio]
Dopamine
[SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology
Hippocampus
Rats
Sprague-Dawley
chemistry.chemical_compound
0302 clinical medicine
[SDV.BDD]Life Sciences [q-bio]/Development Biology
0303 health sciences
Behavior
Animal
Dopaminergic
Subiculum
[SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences
Inhibition
Psychological
medicine.anatomical_structure
[SDV.SP.PHARMA] Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology
Tetrodotoxin
NMDA receptor
Nucleus accumbens
Neurons and Cognition (q-bio.NC)
[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
Ketamine
Locomotion
Subiculum neonatal inactivation
In vivo voltammetry
Prefrontal Cortex
Biology
Cellular and Molecular Neuroscience
03 medical and health sciences
Glutamatergic
mental disorders
medicine
Animals
Microinjection
030304 developmental biology
Ventral striatum
[SDV.NEU.NB] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology
Cell Biology
Corpus Striatum
Animal modelling
030104 developmental biology
Animals
Newborn
chemistry
nervous system
Quantitative Biology - Neurons and Cognition
FOS: Biological sciences
Schizophrenia
[SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology
Neuroscience
030217 neurology & neurosurgery
Zdroj: Neurochemistry International
Neurochemistry International, Elsevier, 2020, 137, pp.104736. ⟨10.1016/j.neuint.2020.104736⟩
Neurochemistry International, 2020, 137, pp.104736. ⟨10.1016/j.neuint.2020.104736⟩
ISSN: 0197-0186
DOI: 10.1016/j.neuint.2020.104736⟩
Popis: For almost two decades schizophrenia has been considered to be a functional disconnection disorder. This functional disconnectivity between several brain regions could have a neurodevelopmental origin. Various approaches suggest the ventral subiculum (SUB) is a particular target region for neurodevelopemental disturbances in schizophrenia. It is also commonly acknowledged that there is a striatal dopaminergic (DA) dysregulation in schizophrenia which may depend on a subiculo-striatal disconnection involving glutamatergic NMDA receptors.; The present study was designed to investigate, in adult rats, the effects of the non-competitive NMDA receptor antagonist ketamine on DA responses in the ventral striatum, or, more specifically, the core part of the nucleus accumbens (Nacc), following postnatal functional inactivation of the SUB. Functional inactivation of the left SUB was carried out by local tetrodotoxin (TTX) microinjection at postnatal day 8 (PND8), i.e. at a critical point in the neurodevelopmental period. DA variations were recorded using in vivo voltammetry in freely moving adult rats (11 weeks). Locomotor activity was recorded simultaneously with the extracellular levels of DA in the core part of the Nacc. Data obtained during the present study showed that after administration of ketamine, the two indexes were higher in TTX animals than PBS animals, the suggestion being that animals microinjected with TTX in the left SUB at PND8 present greater reactivity to ketamine than animals microinjected with PBS. These findings could provide new information regarding the involvement of NMDA glutamatergic receptors in the core part of the Nacc in the pathophysiology of schizophrenia.; Postnatal functional inactivation of the ventral subiculum enhances dopaminergic responses in the core part of the nucleus accumbens following ketamine injection in adult rats
Databáze: OpenAIRE
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