TRIM proteins in neuroblastoma
| Autor: | Guofeng Xu, Yonghu Xu, Zihan Zhang |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Ubiquitin-Protein Ligases Biophysics Biology Biochemistry Trim Tripartite Motif Proteins neuroblastoma 03 medical and health sciences Tumor suppressor proteins 0302 clinical medicine Tripartite Motif Ubiquitin Neuroblastoma medicine Humans Solid tumor Review Articles Molecular Biology Cancer TRIM proteins Post-Translational Modifications Tumor Suppressor Proteins Ubiquitination Cell Biology medicine.disease Tripartite motif family Ubiquitin ligase 030104 developmental biology E3 ubiquitin ligase 030220 oncology & carcinogenesis biology.protein Cancer research Epigenetics |
| Zdroj: | Bioscience Reports |
| ISSN: | 1573-4935 0144-8463 |
| Popis: | Neuroblastoma (NB) is the most common extracranial solid tumor in childhood. Outcome for children with high-risk NB remains unsatisfactory. Accumulating evidence suggests that tripartite motif (TRIM) family proteins express diversely in various human cancers and act as regulators of oncoproteins or tumor suppressor proteins. This review summarizes the TRIM proteins involving in NB and the underlying molecular mechanisms. We expect these new insights will provide important implications for the treatment of NB by targeting TRIM proteins. |
| Databáze: | OpenAIRE |
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