Fibrinogen binding on human platelets. Influence of different heparins and of pentosane polysulfate
| Autor: | J.P. Caen, F. W. Dunn, Claudine Soria, Annick Thomaidis, Gérard Tobelem, Jeannette Soria |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Blood Platelets
medicine.medical_specialty Platelet Aggregation Swine Fibrinogen Polysaccharide Sulfation Intestinal mucosa Polysaccharides Internal medicine medicine Animals Humans Platelet Intestinal Mucosa Lung Pentosan Sulfuric Polyester chemistry.chemical_classification Heparin Fibrinogen binding Hematology Thrombocytopenia Endocrinology chemistry Cattle Pentosane polysulfate medicine.drug |
| Zdroj: | Thrombosis Research. 29:141-148 |
| ISSN: | 0049-3848 |
| DOI: | 10.1016/0049-3848(83)90135-4 |
| Popis: | Unfractionated heparin increased the binding of fibrinogen on ADP-treated platelets. The results varied according to both, the platelets of the donor and the kind of heparin preparation used. Beef lung heparin was more active than porcine intestinal mucosa heparin (p less than 0.02). A fraction of low molecular weight low sulfated heparin, did not significantly increase the binding of fibrinogen, except in one case for which the binding of fibrinogen to platelets was largely increased by standard heparin. On the contrary, pentosane polysulfate, a sulfated polysaccharide (of low molecular weight) significantly increased the binding of fibrinogen (p less than 0.01). |
| Databáze: | OpenAIRE |
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