Combined effect of pH and polysorbates with cyclodextrins on solubilization of naringenin
| Autor: | Calabrò Ml, Silvana Tommasini, D. Raneri, Paola Ficarra, Rita Ficarra |
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| Rok vydání: | 2004 |
| Předmět: |
Naringenin
Chemistry Pharmaceutical Clinical Biochemistry Inorganic chemistry Complex formation Polysorbates Pharmaceutical Science Analytical Chemistry Excipients Surface-Active Agents chemistry.chemical_compound Modified cyclodextrins Phase solubility Drug Discovery Organic chemistry Solubility Micelles Spectroscopy Polysorbate chemistry.chemical_classification Cyclodextrins Aqueous solution Chemistry Estrogen Antagonists food and beverages Polymer Hydrogen-Ion Concentration Solutions Solubilization Flavanones Algorithms |
| Zdroj: | Journal of Pharmaceutical and Biomedical Analysis. 36:327-333 |
| ISSN: | 0731-7085 |
| DOI: | 10.1016/j.jpba.2004.06.013 |
| Popis: | pH control and inclusion complex formation are commonly used as solubilization techniques in formulating ionizable drugs. Naringenin is a weakly acid compound with a low water solubility. The role of both ionized and unionized species of naringenin in solution by complexation with beta-cyclodextrin, 2-hydroxypropyl-beta-cyclodextrin and methyl-beta-cyclodextrin was investigated. This combined use of ionization and complexation increases not only the solubility of the unionized naringenin, but also that of the ionized one. This study puts on evidence the role of pH, pKa and complexation constants in increasing drug total aqueous solubility, determined by the single components in solution, as ionized and unionized naringenin both in free and complexed forms. Moreover, the presence of non-ionic surfactants in the media of complexation gives a positive contribution to the improvement of the solubility of naringenin, alone or in combination with beta-cyclodextrin. |
| Databáze: | OpenAIRE |
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