Mechanism of anaemia in resistant visceral leishmaniasis
| Autor: | M J Pippard, H M Lenicker, D Moir, D J Weatherall |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Ineffective erythropoiesis
Iron 030231 tropical medicine Spleen medicine.disease_cause 03 medical and health sciences 0302 clinical medicine 030225 pediatrics medicine Increased iron Humans Erythropoiesis Pentamidine Iron Radioisotopes business.industry Infant Leishmaniasis Anemia Erythrocyte Aging medicine.disease Haemolysis Infectious Diseases Visceral leishmaniasis medicine.anatomical_structure Antimony Sodium Gluconate Immunology Ferritins Antimonial Leishmaniasis Visceral Parasitology Female business |
| Zdroj: | Annals of tropical medicine and parasitology. 80(3) |
| ISSN: | 0003-4983 |
| Popis: | We have studied the mechanism of a transfusion-dependent anaemia found in a two-year-old Maltese girl with visceral leishmaniasis that was resistant to multiple courses of antimonial therapy. Major factors contributing to the anaemia were haemolysis occurring in both the massively enlarged spleen and liver and haemodilution resulting from expansion of the plasma volume. There was no evidence of significant ineffective erythropoiesis, but a reduced plasma iron in the presence of greatly increased iron stores suggested that reticuloendothelial hyperplasia was accompanied by abnormal iron retention by macrophages typical of the 'anaemia of chronic disorders'. This may limit the erythropoietic response to anaemia in chronic visceral leishmaniasis. |
| Databáze: | OpenAIRE |
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