Hepatitis delta virus induces specific DNA methylation processes in Huh‐7 liver cancer cells
| Autor: | Giorgia Benegiamo, Angelo Andriulli, Valerio Pazienza, Grazia Niro, Vito Guarnieri, Fabrizio Bossa, Manlio Vinciguerra |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
DNA (Cytosine-5-)-Methyltransferase 1
STAT3 Transcription Factor viruses Biophysics DNA methyltransferase Biology medicine.disease_cause Biochemistry Virus Epigenesis Genetic Liver disease Structural Biology Cell Line Tumor HDV Genetics medicine Humans DNA (Cytosine-5-)-Methyltransferases Epigenetics HCC Antigens Viral Molecular Biology Hepatitis B virus Benzenesulfonates Cell Cycle Liver Neoplasms virus diseases Cell Biology DNA Methylation biochemical phenomena metabolism and nutrition medicine.disease Virology digestive system diseases Gene Expression Regulation Neoplastic Aminosalicylic Acids Hepatocellular carcinoma DNA methylation Azacitidine Hepatitis Delta Virus Liver cancer Carcinogenesis E2F1 Transcription Factor |
| Zdroj: | FEBS Letters. 587:1424-1428 |
| ISSN: | 1873-3468 0014-5793 |
| Popis: | Hepatitis delta virus (HDV) is a small, defective RNA virus that can infect only individuals carrying hepatitis B virus. HBV/HDV co-infection results in more severe liver disease than HBV single infection and more rapid progression to cirrhosis and hepatocellular carcinoma (HCC). The epigenetic events involved in hepatocyte transformation towards malignancy in this context are poorly known. Here we report that, in Huh-7 cells, HDV induces DNMT3b expression and is associated to E2F1 transcription factor hypermethylation. Moreover our cell cycle analysis showed that HDV induces G2/M arrest. These findings suggest that HDV could play a role in HCC development at least in part by altering DNA methylation events. A better understanding of the molecular mechanisms involved in HDV-related carcinogenesis could help to identify new therapeutic targets. |
| Databáze: | OpenAIRE |
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